FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255412562> ?p ?o ?g. }

• W4255412562 abstract "Abstract Background The estimation of mean survival is a key consideration when estimating the cost-effectiveness of interventions. Estimation typically requires extrapolation using parametric survival analysis and may be sensitive to choice of functional form. We demonstrate a simple method that allows goodness-of-fit information to be assessed jointly across studies, where such information is believed likely to be exchangeable, to help inform the selection of functional form for parametric survival analysis. Methods Individual patient data for survival was estimated from digitised Kaplan-Meier curves for four trials in advanced soft tissue sarcoma. A range of parametric survival models were fitted. Two approaches were explored for identifying the preferred parametric model: (i) selecting functional forms independently for each study; and (ii) selecting a common functional form across studies. Akaike’s Information Criterion (AIC) or Bayesian Information Criterion (BIC) were used to select optimal functional form. For approach (ii) joint BIC or AIC statistics were calculated for each model by combining the components of the AIC or BIC, respectively, across studies. A bootstrap analysis was conducted to estimate the uncertainty in selection of functional form. Results Estimates of mean survival varied markedly according to choice of functional form. Independent selection led to different functional forms being selected for each study with considerable uncertainty regarding the optimum functional form according to AIC or BIC. In this case study, selecting an optimum functional form based on joint AIC or BIC across studies reduced uncertainty in model selection and variance in mean survival compared to selection of functional form independently. Conclusion Extrapolation of estimates of survival may be sensitive to choice of functional form. If it is believed, a priori, reasonable to share information regarding the choice of functional form for survival analysis across studies, estimating joint goodness-of-fit information across studies could reduce uncertainty and lead to more reliable estimates of mean survival and cost-effectiveness." @default.
• W4255412562 created "2022-05-12" @default.
• W4255412562 creator A5003388016 @default.
• W4255412562 creator A5003412990 @default.
• W4255412562 creator A5039505685 @default.
• W4255412562 date "2020-08-13" @default.
• W4255412562 modified "2023-10-16" @default.
• W4255412562 title "Can’t see the wood for the trees: Using common likelihoods to share information regarding selection of functional form in survival analysis" @default.
• W4255412562 doi "https://doi.org/10.21203/rs.3.rs-55390/v1" @default.
• W4255412562 hasPublicationYear "2020" @default.
• W4255412562 type Work @default.
• W4255412562 citedByCount "0" @default.
• W4255412562 crossrefType "posted-content" @default.
• W4255412562 hasAuthorship W4255412562A5003388016 @default.
• W4255412562 hasAuthorship W4255412562A5003412990 @default.
• W4255412562 hasAuthorship W4255412562A5039505685 @default.
• W4255412562 hasBestOaLocation W42554125621 @default.
• W4255412562 hasConcept C10515644 @default.
• W4255412562 hasConcept C105795698 @default.
• W4255412562 hasConcept C107673813 @default.
• W4255412562 hasConcept C117251300 @default.
• W4255412562 hasConcept C126674687 @default.
• W4255412562 hasConcept C132480984 @default.
• W4255412562 hasConcept C149782125 @default.
• W4255412562 hasConcept C154945302 @default.
• W4255412562 hasConcept C160234255 @default.
• W4255412562 hasConcept C168136583 @default.
• W4255412562 hasConcept C17634605 @default.
• W4255412562 hasConcept C2776709221 @default.
• W4255412562 hasConcept C33923547 @default.
• W4255412562 hasConcept C41008148 @default.
• W4255412562 hasConcept C81917197 @default.
• W4255412562 hasConcept C93959086 @default.
• W4255412562 hasConceptScore W4255412562C10515644 @default.
• W4255412562 hasConceptScore W4255412562C105795698 @default.
• W4255412562 hasConceptScore W4255412562C107673813 @default.
• W4255412562 hasConceptScore W4255412562C117251300 @default.
• W4255412562 hasConceptScore W4255412562C126674687 @default.
• W4255412562 hasConceptScore W4255412562C132480984 @default.
• W4255412562 hasConceptScore W4255412562C149782125 @default.
• W4255412562 hasConceptScore W4255412562C154945302 @default.
• W4255412562 hasConceptScore W4255412562C160234255 @default.
• W4255412562 hasConceptScore W4255412562C168136583 @default.
• W4255412562 hasConceptScore W4255412562C17634605 @default.
• W4255412562 hasConceptScore W4255412562C2776709221 @default.
• W4255412562 hasConceptScore W4255412562C33923547 @default.
• W4255412562 hasConceptScore W4255412562C41008148 @default.
• W4255412562 hasConceptScore W4255412562C81917197 @default.
• W4255412562 hasConceptScore W4255412562C93959086 @default.
• W4255412562 hasLocation W42554125621 @default.
• W4255412562 hasOpenAccess W4255412562 @default.
• W4255412562 hasPrimaryLocation W42554125621 @default.
• W4255412562 hasRelatedWork W10970137 @default.
• W4255412562 hasRelatedWork W12288669 @default.
• W4255412562 hasRelatedWork W1752089 @default.
• W4255412562 hasRelatedWork W3999907 @default.
• W4255412562 hasRelatedWork W4373190 @default.
• W4255412562 hasRelatedWork W4796181 @default.
• W4255412562 hasRelatedWork W5532765 @default.
• W4255412562 hasRelatedWork W5686477 @default.
• W4255412562 hasRelatedWork W7276022 @default.
• W4255412562 hasRelatedWork W8691178 @default.
• W4255412562 isParatext "false" @default.
• W4255412562 isRetracted "false" @default.
• W4255412562 workType "article" @default.