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- W4255450109 abstract "Compulsion underlying addiction is highlighted in a study by Pascoli and colleagues. They used genetically modified mice to stimulate dopaminergic neurons in the ventral tegmental area by pressing a lever that activated an optogenetic implant. After 12–15 days of acquisition, 66 (61%) of 109 mice continued to self-stimulate dopaminergic neurons optogenetically despite receiving electric shocks upon pressing the lever (p<0·05 persevering vs renouncing mice for punished session). Potentiation of the connections between the orbitofrontal cortex and dorsal striatum in renouncing mice after punishment subsequently led to these mice compulsively pressing the lever; in mice that showed compulsive behaviour with punishment, inhibition of these connections reduced lever pressing. Childhood seizures and risk of psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort studyChildren with epilepsy and febrile seizures—with and without concomitant epilepsy—are at increased risk of developing a broad range of psychiatric disorders in later life. Clarification of the underlying mechanisms attributable to these associations is needed to identify potential options for prevention. Full-Text PDF" @default.
- W4255450109 created "2022-05-12" @default.
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- W4255450109 date "2019-02-01" @default.
- W4255450109 modified "2023-09-25" @default.
- W4255450109 title "Research round up" @default.
- W4255450109 doi "https://doi.org/10.1016/s2215-0366(19)30008-2" @default.
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