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- W4255464802 abstract "In many cell types, Ca2+ signals are organized in the form of repetitive spikes. The frequency of these intracellular Ca2+ oscillations increases with the level of stimulation, suggesting the existence of a frequency encoding phenomenon. The question arises as to how the frequency of Ca2+ oscillations can be decoded inside the cell. Ca2+/calmodulin kinase II has long been proposed as an attractive candidate, as it is a key target of Ca2+ signals. By immobilizing the Ca2+/calmodulin kinase II and subjecting it to pulses of Ca2+ of variable amplitude, duration, and frequency, De Koninck and Schulman(1) have shown for the first time that the autonomous activity of Ca2+/calmodulin kinase II is highly sensitive to the temporal pattern of Ca2+ oscillations. BioEssays 20:607–610, 1998.© 1998 John Wiley & Sons Inc." @default.
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- W4255464802 date "1998-08-01" @default.
- W4255464802 modified "2023-09-26" @default.
- W4255464802 title "CaM kinase II as frequency decoder of Ca2 oscillations" @default.
- W4255464802 doi "https://doi.org/10.1002/(sici)1521-1878(199808)20:8<607::aid-bies2>3.3.co;2-2" @default.
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