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- W4255470010 abstract "By 1995, the US National Institutes of Health (NIH) had spent only $100 million on vaccine research out of a total AIDS budget of $1.3 billion. Planned spending for 1999 is almost 80% higher. Now even though vaccine research has become NIH's top priority, allocated $180 million of the projected $1.73 billion budget, research into HIV etiology and pathogenesis has consumed $526 million, and therapeutics $482 million. More funds could be invested in vaccine research, but the variability of HIV is probably the most important challenge facing HIV vaccine researchers. Moreover, researchers know neither what comprises protective immunity, nor which animal model is best suited to test vaccine candidates, and there are many competing vaccine approaches. An enormous gap remains between a vaccine candidate and product development. The pace of HIV vaccine development must be accelerated, with developing countries involved in the effort as full and equal partners with the more developed countries. Only 2 phase III vaccine trials are underway, a US study with a clade B gp120 candidate, and a Thai study with a clade B/E gp120 product. Results will be forthcoming in 2003." @default.
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- W4255470010 date "1998-10-01" @default.
- W4255470010 modified "2023-09-29" @default.
- W4255470010 title "An HIV vaccine: how long must we wait" @default.
- W4255470010 doi "https://doi.org/10.1016/s0140-6736(98)00044-0" @default.
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