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- W4255471036 abstract "<h3>To the Editor.—</h3> I fully agree with Neal R. Cutler, MD, and Jon F. Heiser, MD (240:2264, 1978), in their article The Tricyclic Antidepressants, except for one point regarding initial dosage. It has been my experience that one should start at a dosage equivalent to not more than 50 mg/day of imipramine hydrochloride. This is certainly true if 25 mg twice a day is administered, because a number of patients will become sedated and feel as if their depression has been intensified. Actually, I initiate therapy at 25 mg/day to make certain that side effects are absolutely minimal and also to give me a concrete idea as to how this particular patient relates to the taking of medication. After one to two days, I increase the dosage to 50 mg/day for one to two days and then raise it to the 75 mg/day that Cutler and Heiser recommended. The dosage" @default.
- W4255471036 created "2022-05-12" @default.
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- W4255471036 date "1979-08-10" @default.
- W4255471036 modified "2023-09-25" @default.
- W4255471036 title "Tricyclic Antidepressants" @default.
- W4255471036 doi "https://doi.org/10.1001/jama.1979.03300060013005" @default.
- W4255471036 hasPublicationYear "1979" @default.
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