Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255486175> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4255486175 abstract "Trastuzumab, a monoclonal antibody targeted against the human epidermal growth factor receptor 2 (HER2) is utilized for the treatment of human breast cancer (1, 2), but a complete understanding of how tumor signal transduction is modulated by trastuzumab treatment is lacking. By mining published and public microarray and gene expression data (3, 4) from the primary tumors of patients treated with trastuzumab, we found that two components of the interleukin-1 cytokine signaling pathway, interleukin-1α (IL-1α) and the interleukin-1 receptor antagonist, IL-1RN, were among the genes most differentially expressed in the primary tumors of patients treated with trastuzumab. While IL-1α cytokine levels were increased, IL-1RN levels were decreased. Thus, the administration of trastuzumab in patients with breast cancer is associated with increased expression of a cytokine demonstrated to promote breast cancer progression and decreased expression of an interleukin receptor antagonist with metastasis suppressive properties in breast cancer human xenograft models in vivo (5, 6)." @default.
- W4255486175 created "2022-05-12" @default.
- W4255486175 creator A5024900493 @default.
- W4255486175 date "2020-11-28" @default.
- W4255486175 modified "2023-10-16" @default.
- W4255486175 title "Interleukin-1α and the interleukin-1 receptor antagonist (IL-1RN) are differentially expressed in the primary tumors of breast cancer patients treated with trastuzumab." @default.
- W4255486175 doi "https://doi.org/10.31219/osf.io/89n52" @default.
- W4255486175 hasPublicationYear "2020" @default.
- W4255486175 type Work @default.
- W4255486175 citedByCount "0" @default.
- W4255486175 crossrefType "posted-content" @default.
- W4255486175 hasAuthorship W4255486175A5024900493 @default.
- W4255486175 hasBestOaLocation W42554861752 @default.
- W4255486175 hasConcept C121608353 @default.
- W4255486175 hasConcept C126322002 @default.
- W4255486175 hasConcept C143998085 @default.
- W4255486175 hasConcept C149892131 @default.
- W4255486175 hasConcept C170493617 @default.
- W4255486175 hasConcept C189860405 @default.
- W4255486175 hasConcept C200155923 @default.
- W4255486175 hasConcept C2776885963 @default.
- W4255486175 hasConcept C2778122271 @default.
- W4255486175 hasConcept C2778690821 @default.
- W4255486175 hasConcept C2779013556 @default.
- W4255486175 hasConcept C2779786085 @default.
- W4255486175 hasConcept C502942594 @default.
- W4255486175 hasConcept C530470458 @default.
- W4255486175 hasConcept C71924100 @default.
- W4255486175 hasConcept C74172505 @default.
- W4255486175 hasConceptScore W4255486175C121608353 @default.
- W4255486175 hasConceptScore W4255486175C126322002 @default.
- W4255486175 hasConceptScore W4255486175C143998085 @default.
- W4255486175 hasConceptScore W4255486175C149892131 @default.
- W4255486175 hasConceptScore W4255486175C170493617 @default.
- W4255486175 hasConceptScore W4255486175C189860405 @default.
- W4255486175 hasConceptScore W4255486175C200155923 @default.
- W4255486175 hasConceptScore W4255486175C2776885963 @default.
- W4255486175 hasConceptScore W4255486175C2778122271 @default.
- W4255486175 hasConceptScore W4255486175C2778690821 @default.
- W4255486175 hasConceptScore W4255486175C2779013556 @default.
- W4255486175 hasConceptScore W4255486175C2779786085 @default.
- W4255486175 hasConceptScore W4255486175C502942594 @default.
- W4255486175 hasConceptScore W4255486175C530470458 @default.
- W4255486175 hasConceptScore W4255486175C71924100 @default.
- W4255486175 hasConceptScore W4255486175C74172505 @default.
- W4255486175 hasLocation W42554861751 @default.
- W4255486175 hasLocation W42554861752 @default.
- W4255486175 hasOpenAccess W4255486175 @default.
- W4255486175 hasPrimaryLocation W42554861751 @default.
- W4255486175 hasRelatedWork W1040485 @default.
- W4255486175 hasRelatedWork W13600379 @default.
- W4255486175 hasRelatedWork W14175801 @default.
- W4255486175 hasRelatedWork W16226371 @default.
- W4255486175 hasRelatedWork W16909223 @default.
- W4255486175 hasRelatedWork W18039963 @default.
- W4255486175 hasRelatedWork W20193601 @default.
- W4255486175 hasRelatedWork W2440726 @default.
- W4255486175 hasRelatedWork W2441151 @default.
- W4255486175 hasRelatedWork W3598312 @default.
- W4255486175 isParatext "false" @default.
- W4255486175 isRetracted "false" @default.
- W4255486175 workType "article" @default.