FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255568223> ?p ?o ?g. }

• W4255568223 endingPage "366" @default.
• W4255568223 startingPage "360" @default.
• W4255568223 abstract "Liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), the principal enzymes responsible for the oxidation of ethanol, are polymorphic at the ADH2, ADH3 and ALDH2 loci in human beings. Our previous studies have shown that, compared with nonalcoholic individuals, Chinese alcoholic patients without liver disease had significantly lower frequencies of the ADH2*2 and ADH3*1 alleles, which encode high maximum velocity β2- and γ1-ADH subunits, respectively, as well as a lower frequency of the ALDH2*2 allele, which encodes an enzymatically inactive subunit. The data strongly suggest that genetic variation in both ADH and ALDH may influence drinking behavior and the risk of alcoholism developing through acetaldehyde formation. To further investigate the possible role of acetaldehyde in the pathogenesis of alcoholic liver disease, we determined the ADH and ALDH genotype frequencies in patients with alcohol-related cirrhosis (n = 27), viral hepatitis-related cirrhosis (n = 29) and gastric and duodenal ulcer without relevance to alcohol (n = 30). We developed a new restriction fragment length polymorphism method to genotype the mutant and normal ALDH2 alleles by using polymerase chain reaction–directed mutagenesis, which proved to be simpler and faster than the conventional detection methods that use hybridization with allele-specific oligonucleotide probes. We found that the frequencies of the alleles ADH2*2 (57), ADH3*1 (78) and ALDH2*2 (9) in the alcoholic cirrhotic patients were significantly lower than those in the healthy controls and in the patients with cirrhosis from viral hepatitis and with gastric and duodenal ulcer. No significant differences in the allele frequencies of these three genes between the alcoholic cirrhotic patients and the alcohol-dependent subjects without severe liver injury were found, although the alcoholic cirrhosis group tended to have a higher incidence of ALDH2*1/*2 heterozygotes (5 of 27) than did the alcohol-dependent group (6 of 50). The results confirm previous studies that the ADH2*2, ADH3*1 and ALDH2*2 genes can affect predisposition to alcoholism in Chinese patients and suggest that the mutant ALDH2*2 gene may influence susceptibility to alcoholic cirrhosis. (Hepatology 1994;19:360–366)." @default.
• W4255568223 created "2022-05-12" @default.
• W4255568223 creator A5005792320 @default.
• W4255568223 date "1994-02-01" @default.
• W4255568223 modified "2023-10-06" @default.
• W4255568223 title "Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients" @default.
• W4255568223 doi "https://doi.org/10.1016/0270-9139(94)90013-2" @default.
• W4255568223 hasPublicationYear "1994" @default.
• W4255568223 type Work @default.
• W4255568223 citedByCount "25" @default.
• W4255568223 crossrefType "journal-article" @default.
• W4255568223 hasAuthorship W4255568223A5005792320 @default.
• W4255568223 hasConcept C104317684 @default.
• W4255568223 hasConcept C126322002 @default.
• W4255568223 hasConcept C135763542 @default.
• W4255568223 hasConcept C180754005 @default.
• W4255568223 hasConcept C25747580 @default.
• W4255568223 hasConcept C2777214474 @default.
• W4255568223 hasConcept C2777344606 @default.
• W4255568223 hasConcept C2777575235 @default.
• W4255568223 hasConcept C2777595113 @default.
• W4255568223 hasConcept C2780161600 @default.
• W4255568223 hasConcept C2780732942 @default.
• W4255568223 hasConcept C2781066024 @default.
• W4255568223 hasConcept C30153976 @default.
• W4255568223 hasConcept C31467283 @default.
• W4255568223 hasConcept C3175096 @default.
• W4255568223 hasConcept C37463918 @default.
• W4255568223 hasConcept C54355233 @default.
• W4255568223 hasConcept C55493867 @default.
• W4255568223 hasConcept C71924100 @default.
• W4255568223 hasConcept C86803240 @default.
• W4255568223 hasConceptScore W4255568223C104317684 @default.
• W4255568223 hasConceptScore W4255568223C126322002 @default.
• W4255568223 hasConceptScore W4255568223C135763542 @default.
• W4255568223 hasConceptScore W4255568223C180754005 @default.
• W4255568223 hasConceptScore W4255568223C25747580 @default.
• W4255568223 hasConceptScore W4255568223C2777214474 @default.
• W4255568223 hasConceptScore W4255568223C2777344606 @default.
• W4255568223 hasConceptScore W4255568223C2777575235 @default.
• W4255568223 hasConceptScore W4255568223C2777595113 @default.
• W4255568223 hasConceptScore W4255568223C2780161600 @default.
• W4255568223 hasConceptScore W4255568223C2780732942 @default.
• W4255568223 hasConceptScore W4255568223C2781066024 @default.
• W4255568223 hasConceptScore W4255568223C30153976 @default.
• W4255568223 hasConceptScore W4255568223C31467283 @default.
• W4255568223 hasConceptScore W4255568223C3175096 @default.
• W4255568223 hasConceptScore W4255568223C37463918 @default.
• W4255568223 hasConceptScore W4255568223C54355233 @default.
• W4255568223 hasConceptScore W4255568223C55493867 @default.
• W4255568223 hasConceptScore W4255568223C71924100 @default.
• W4255568223 hasConceptScore W4255568223C86803240 @default.
• W4255568223 hasIssue "2" @default.
• W4255568223 hasLocation W42555682231 @default.
• W4255568223 hasOpenAccess W4255568223 @default.
• W4255568223 hasPrimaryLocation W42555682231 @default.
• W4255568223 hasRelatedWork W113344150 @default.
• W4255568223 hasRelatedWork W1200098 @default.
• W4255568223 hasRelatedWork W1604627024 @default.
• W4255568223 hasRelatedWork W2021590859 @default.
• W4255568223 hasRelatedWork W2065239415 @default.
• W4255568223 hasRelatedWork W2125919518 @default.
• W4255568223 hasRelatedWork W2380880325 @default.
• W4255568223 hasRelatedWork W2398408498 @default.
• W4255568223 hasRelatedWork W2441750594 @default.
• W4255568223 hasRelatedWork W2415759949 @default.
• W4255568223 hasVolume "19" @default.
• W4255568223 isParatext "false" @default.
• W4255568223 isRetracted "false" @default.
• W4255568223 workType "article" @default.