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- W4255568242 abstract "As many of the ‘threat chemicals’ so closely resemble endogenous signal molecules, it is entirely logical that the biotransforming enzyme systems such as the Cytochrome P450 (CYP) would evolve to dismantle these threat molecules as well as build and dismantle endogenous ones. It has long been known in folk medicine that many plants have hormone-like effects that are potent enough to influence female reproductive cycles. MicroRNAs originating from plant species can not only survive our digestive systems but also influence human gene expression. Aside from their biotransformational roles in steroid biosynthesis and drug/toxin clearance, CYPs carry out a wide array of metabolic activities that are essential to homeostasis throughout the body. Although the gut metabolizes many drugs, the liver is the main biotransforming organ, and the CYPs and other metabolizing enzymes reside in the hepatocytes." @default.
- W4255568242 created "2022-05-12" @default.
- W4255568242 date "2020-02-21" @default.
- W4255568242 modified "2023-10-03" @default.
- W4255568242 title "Drug Biotransformational Systems – Origins and Aims" @default.
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- W4255568242 doi "https://doi.org/10.1002/9781119658016.ch2" @default.
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