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• W4255605666 abstract "The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity. A series of C-6 biarylmethylamino derivatives was prepared addressing modifications on the C-6 biaryl rings, N-9 and C-2 positions to provide compounds that displayed potent cytotoxic activity against tumor cell lines. In particular, derivative 21h demonstrated a >750-fold improvement in the growth inhibition of HeLa cells compared to roscovitine (2)." @default.
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• W4255605666 date "2009-12-01" @default.
• W4255605666 modified "2023-09-27" @default.
• W4255605666 title "Biaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part I" @default.
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• W4255605666 doi "https://doi.org/10.1016/j.bmcl.2009.10.025" @default.
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