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• W4255646721 abstract "<p>Molnupiravir (MK-4482) is an investigational direct-acting antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand for this compound, it was critical to develop a sustainable and efficient synthesis from commodity raw materials. The three-step route that we report here embodies the shortest possible synthesis to molnupiravir, and was enabled through the invention of a novel biocatalytic cascade and final condensation step. Each step occurs in over 95% yield and only utilizes widely available commodity reagents and simple operations. Compared to the initial route, the new route is 70% shorter, and approximately seven-fold higher in overall yield. <br></p>" @default.
• W4255646721 created "2022-05-12" @default.
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• W4255646721 date "2020-12-23" @default.
• W4255646721 modified "2023-10-18" @default.
• W4255646721 title "Evolving to an Ideal Synthesis of Molnupiravir, an Investigational Treatment for COVID-19" @default.
• W4255646721 doi "https://doi.org/10.26434/chemrxiv.13472373" @default.
• W4255646721 hasPublicationYear "2020" @default.
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