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• W4255659046 abstract "Adipocytic neoplasms are among the most common mesenchymal neoplasms. In the last decade, some new entities have been delineated and new concepts introduced. Myolipoma is a benign lesion composed of mature adipocytic tissue intermingled with smooth muscle fibers. Clinically it usually arises in the abdomen, retroperitoneum or abdominal wall of adults. Chondroid lipoma is a deeply seated benign lesion located in the limbs, trunk and head and neck region of adult females. Microscopically it is composed by an admixture of mature adipocytes, eosinophilic chondroblast-like cells and lipoblasts set in myxochondroid background. Spindle cell liposarcoma represents a rare variant of well-differentiated (WD) liposarcoma with tendency to recur locally. Morphologically it is composed of a neural-like spindle cell proliferation associated with an atypical lipomatous component. The fact that WD liposarcoma shows a risk of local recurrence but no potential for metastasis has led to the introduction of the term atypical lipomatous tumour. Well-differentiated liposarcoma and atypical lipoma however, should be considered synonyms. De-differentiated liposarcoma is characterised by the transition from low grade to high grade non-lipogenic morphology within a WD liposarcoma. Heterologous differentiation is seen in about 5% of cases and, a distinctive neural-like whorling pattern of de-differentiation has been recently described. Surprisingly, the clinical behaviour of de-differentiated liposarcoma is less aggressive than in other high grade pleomorphic sarcomas, at least in part as a consequence of peculiar genetic as well as molecular mechanisms. Myxoid and round cell liposarcoma, even if still classified by the World Health Organisation as two distinct subtypes, represent both morphologically and cytogenetically a spectrum of myxoid adipocytic neoplasia. Considering currently available data, liposarcoma can be classified into three main groups: 1) WD liposarcoma (including adipocytic, sclerosing, inflammatory, spindle cell and de-differentiated variants), characterised by ring or long marker chromosomes derived from chromosome 12; 2) myxoid and round cell liposarcoma, characterised in most cases by a reciprocal translocation: t(12; 16)(q13; p11); and 3) pleomorphic liposarcoma, characterised by complex karyotypes." @default.
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• W4255659046 date "2001-03-01" @default.
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• W4255659046 title "Lipomatous tumours" @default.
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• W4255659046 doi "https://doi.org/10.1054/cdip.2000.0056" @default.
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