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- W4255684344 abstract "Abstract Objective : This study was designed to identify the differentially expressed mRNA, microRNA (miRNA), and long non-coding RNA (lncRNA) and their functions in pancreatic cancer (PC). Methods: The expression data of PC and normal samples were downloaded from the GEO database. The expression data of pancreatic head (H), body (B), and tail (T) were downloaded from the TCGA database. After data preprocessing, the differential analyses between PC vs. Normal, H vs. B, H vs. T, and T vs. B were performed. Overlapping genes between PC vs. Normal and the different locations (the union of genes among T vs. B, T vs. H, and B vs. H) were selected. The competing endogenous RNAs (ceRNA) network was constructed based on co-expression analysis and prediction of targets, followed by functional enrichment analysis. Construction of an mRNA prognosis risk model and screening of prognostic factors were performed using Cox univariate/multivariate regression analysis, followed by Nomogram model construction. Finally, the gene-drug interactions were predicted for the DE-mRNA. Results: A five-mRNA prognostic model (GRHL2+CACNA1A+GRM1+UPK1B+PKHD1) was constructed, and the risk score was relatively increased with the increased expression of the GRHL2, PKHD1, and UPK1B, and the decreased expression of CACNA1A and GRM1. Compared with pancreatic body/tail cancer, the expression of GRHL2 was increased, while the expression of CACNA1A and GRM1 was decreased in pancreatic head cancer. LncRNA AC006369.2-miR-146a-5p-CACNA1A/GRM1 was a regulatory axis in the ceRNA network. Verapamil was predicted to be an antagonist of CACNA1A. Conclusion: Our results provide a new direction for the accurate diagnosis and treatment of PC and for investigating the mechanism of PC." @default.
- W4255684344 created "2022-05-12" @default.
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- W4255684344 date "2019-09-23" @default.
- W4255684344 modified "2023-10-16" @default.
- W4255684344 title "Identification of novel biomarkers and prognostic value of the location (head, body, or tail) of pancreatic cancer" @default.
- W4255684344 doi "https://doi.org/10.21203/rs.2.14728/v1" @default.
- W4255684344 hasPublicationYear "2019" @default.
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