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- W4255690844 abstract "Gastrointestinal myoelectric activity was investigated in conscious rabbits with chronically implanted electrodes. As rabbit stomach is never empty, food was removed 1 h before the beginning of recordings. Propagated activity fronts spontaneously started in the jejunum without associated changes in the antroduodenal area. Intravenous administration of either motilin (600–1500 ng/kg) or erythromycin (5–50 μg/kg) did not modify antral activity, but simultaneously increased duodenal and jejunal activity in a dose-dependent manner. Spontaneous and induced jejunal activity fronts showed some similarities. However, those induced did not propagate and were not followed by a quiescence period. The effects of motilin (900 ng/kg) and erythromycin (25 μg/kg) were resistant to atropine (0.5 mg/kg), hexamethonium (2 mg/kg), or ondansetron (0.5 mg/kg). These results suggest that motilin is not a physiological modulator of the migrating myoelectric complex (MMC) in rabbits. Moreover, neither cholinergic nor 5-HT3 receptors are involved in either motilin- or erythromycin-induced actions." @default.
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- W4255690844 date "1996-10-02" @default.
- W4255690844 modified "2023-09-30" @default.
- W4255690844 title "Effect of Motilin on Gastrointestinal Myoelectric Activity in Conscious Rabbits" @default.
- W4255690844 doi "https://doi.org/10.1016/s0196-9781(96)00144-1" @default.
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