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- W4255758032 abstract "Abstract Background: Stroke is the second leading cause of deaths worldwide, and 53.4% of the stroke survivors suffer from post-stroke cognitive impairment. Post-stroke cognitive impairment can increase hospitalization rate and cost of care, and decrease the quality of life of stroke patients. To date, multiple cognitive rehabilitation interventions have been tested in stroke populations with post-stroke cognitive impairment. However, the most efficacious intervention has not been established. This systematic review aims to compare the efficacy of cognitive rehabilitation interventions for patients with post-stroke cognitive impairment. Methods: We will search MEDLINE, EMBASE, CENTRAL, PsycINFO, CINAHL, PubMed and clinical trial registries to identify eligible randomized clinical trials with no restrictions in the date of publication and language. Studies conducted with patient aged 18 or over, with the presence of cognitive impairment after being diagnosed with stroke will be included. Studies will be restricted to randomized controlled trials comparing a cognitive rehabilitation intervention with another intervention. The primary outcome is any clinical changes in general or specific cognitive domain (e.g. executive function, attention, memory or perception). The secondary outcomes that will be collected include adverse effects (e.g. stroke, disability or mortality) and quality of life. Two independent reviewers will assess articles to identify trials eligible for inclusion. Data extraction and risk of bias assessment of the included studies will also be done independently. Any discrepancies will be solved by discussion, or a third reviewer will be consulted if necessary. A meta-analysis will be carried out if appropriate. Discussion: This systematic review for patients with post-stroke cognitive impairment will assess efficacy of cognitive rehabilitation interventions. And our results will help clinical decision-making and support the development of clinical practice guidelines. Systematic review registration: PROSPERO CRD42020173988" @default.
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- W4255758032 date "2020-09-09" @default.
- W4255758032 modified "2023-09-26" @default.
- W4255758032 title "Cognitive Rehabilitation Interventions After Stroke: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials" @default.
- W4255758032 doi "https://doi.org/10.21203/rs.3.rs-73071/v1" @default.
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