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• W4255872002 abstract "In 1982, a group of researchers reported that tissues lost to periodontal disease could be regenerated by the use of a surgical technique known as guided tissue regeneration. Since then, tremendous progress has been made in adapting these techniques to jaw reconstruction. Along with the development of guided tissue regeneration procedures were the development of many first-generation and second-generation membrane barriers. The current first-generation barriers available are Gore-Tex and TefGen. Both are made from 100% medical-grade polytetrafluoroethylene, but differ in that TefGen is full density and is impervious to bacteria. Gore-Tex is expanded polytetrafluoroethylene (e-PTFE) with pores. The biodegradable second-generation membrane barriers available are Vicryl, BioMend, BioGide, OsseoQuest, and Capset. Vicryl Mesh is composed of woven polyglactin 910. The pore size allows passage of fluids. It is resorbed in 2 to 6 months. BioMend completely resorbed in 4 to 8 weeks. The material must be hydrated in sterile water to saline for approximately 15 minutes before final placements. BioGide is composed of collagen types I and II in a bilayer membrane. It resorbs in 4 months. OsseoQuest is a barrier made of polyglycolic acid and polylactic acid with trimethylene carbonate. It resorbs in 6 months. Capset composed of calcium sulfate. It must be used in conjunction with bone grafting material. It remains in the tissues for up to 30 days. All have been used in clinical studies with varying success. A critical point for success of second-generation membranes is the rate of degradation. The longer the material maintains barrier function, the better the results. Thus, bioabsorbables may not perform as well as nonabsorbables. A study performed by Sandberg, Dahlin, and Linde found bioabsorbable membranes to be as efficient as (e-PTFE) and a valid alternative. Third-generation membranes barriers are being developed that are impregnated with polypeptide growth factors, including platelet growth factor, insulin-like growth factor, transforming growth factor-B, fibroblast growth factor or bone morphogenic protein. Current research shows some of theses materials to be promising. Both first- and second-generation membrane barriers can be used in the treatment of osseous defects with implants, augmentation of atrophic ridges, treatment of failing implants and extraction sites. When treating osseous defects with implants using biodegradable second-generation membrane, the dilemma arises in now knowing the amount of regeneration you obtained. Thus, familiarity with these materials along with their applications will increase the success ratio of guided tissue regeneration in jaw reconstruction. References Becker W, Beck B: Clinical applications of guided tissue regeneration: Surgical considerations. Periodontology 1:1993, 2000 O’Neal R, Wang H: Cells and materials involved in guided tissue regeneration. Curr Opin Periodontol 1994 Jovanovic SA: bone rehabilitation to achieve optimal aesthetics. Pract Periodont Aesthetic Dent 9, 1997" @default.
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• W4255872002 date "2004-08-01" @default.
• W4255872002 modified "2023-09-24" @default.
• W4255872002 title "Guided tissue regeneration in jaw reconstruction: Review and applications" @default.
• W4255872002 doi "https://doi.org/10.1016/j.joms.2004.06.003" @default.
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