Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255936150> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4255936150 endingPage "114" @default.
- W4255936150 startingPage "110" @default.
- W4255936150 abstract "Dehydroepiandrosterone(DHEA) and DHEA-S are steroids that are abundantly produced by the adrenal gland. Plasma concentrations of DHEA and DHEA-S increase during adrenarche but decrease steadily after puberty. Although DHEA and DHEA-S have few intrinsic androgenic actions, they have recently attracted widespread attention due to their beneficial anti-aging effects. We clarified the beneficial effects of DHEA as an anti-aging steroid with regard to its stimulation of the immune system and its anti-diabetes, anti-atherosclerosis, anti-dementia (neurosteroid), anti-obesity and anti-osteoporosis effects. There are two possible biochemical and molecular mechanisms: direct action via the DHEA receptor on the target gene; and indirect action. We identified a high affinity of DHEA binding in human T-lymphocytes by searching for the target genes that are induced in activated T-lymphocytes in the presence of DHEA, determined the gene sequence and named DHEA-induced dual p38-specific phosphatase (DDSP). DDSP transgenic mice have been created to identify the anti-aging effects of DDSP. The conversion of DHEA to estrone by cytochrome P450 aromatase in primary cultured human osteoblasts was clarified. We are currently undertaking an open trial of DHEA replacement therapy." @default.
- W4255936150 created "2022-05-12" @default.
- W4255936150 creator A5012048006 @default.
- W4255936150 creator A5020123456 @default.
- W4255936150 creator A5020629981 @default.
- W4255936150 creator A5034073288 @default.
- W4255936150 creator A5064192882 @default.
- W4255936150 creator A5082846066 @default.
- W4255936150 creator A5088174367 @default.
- W4255936150 date "2004-01-01" @default.
- W4255936150 modified "2023-10-16" @default.
- W4255936150 title "Adrenopause" @default.
- W4255936150 doi "https://doi.org/10.1159/000080509" @default.
- W4255936150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15539809" @default.
- W4255936150 hasPublicationYear "2004" @default.
- W4255936150 type Work @default.
- W4255936150 citedByCount "15" @default.
- W4255936150 countsByYear W42559361502012 @default.
- W4255936150 countsByYear W42559361502013 @default.
- W4255936150 countsByYear W42559361502015 @default.
- W4255936150 countsByYear W42559361502017 @default.
- W4255936150 countsByYear W42559361502021 @default.
- W4255936150 countsByYear W42559361502022 @default.
- W4255936150 countsByYear W42559361502023 @default.
- W4255936150 crossrefType "journal-article" @default.
- W4255936150 hasAuthorship W4255936150A5012048006 @default.
- W4255936150 hasAuthorship W4255936150A5020123456 @default.
- W4255936150 hasAuthorship W4255936150A5020629981 @default.
- W4255936150 hasAuthorship W4255936150A5034073288 @default.
- W4255936150 hasAuthorship W4255936150A5064192882 @default.
- W4255936150 hasAuthorship W4255936150A5082846066 @default.
- W4255936150 hasAuthorship W4255936150A5088174367 @default.
- W4255936150 hasConcept C121207290 @default.
- W4255936150 hasConcept C126322002 @default.
- W4255936150 hasConcept C134018914 @default.
- W4255936150 hasConcept C168258287 @default.
- W4255936150 hasConcept C170493617 @default.
- W4255936150 hasConcept C2776992908 @default.
- W4255936150 hasConcept C2777911890 @default.
- W4255936150 hasConcept C2779279991 @default.
- W4255936150 hasConcept C2780193516 @default.
- W4255936150 hasConcept C2780902042 @default.
- W4255936150 hasConcept C44796713 @default.
- W4255936150 hasConcept C71315377 @default.
- W4255936150 hasConcept C71924100 @default.
- W4255936150 hasConcept C98274493 @default.
- W4255936150 hasConceptScore W4255936150C121207290 @default.
- W4255936150 hasConceptScore W4255936150C126322002 @default.
- W4255936150 hasConceptScore W4255936150C134018914 @default.
- W4255936150 hasConceptScore W4255936150C168258287 @default.
- W4255936150 hasConceptScore W4255936150C170493617 @default.
- W4255936150 hasConceptScore W4255936150C2776992908 @default.
- W4255936150 hasConceptScore W4255936150C2777911890 @default.
- W4255936150 hasConceptScore W4255936150C2779279991 @default.
- W4255936150 hasConceptScore W4255936150C2780193516 @default.
- W4255936150 hasConceptScore W4255936150C2780902042 @default.
- W4255936150 hasConceptScore W4255936150C44796713 @default.
- W4255936150 hasConceptScore W4255936150C71315377 @default.
- W4255936150 hasConceptScore W4255936150C71924100 @default.
- W4255936150 hasConceptScore W4255936150C98274493 @default.
- W4255936150 hasIssue "Suppl. 3" @default.
- W4255936150 hasLocation W42559361501 @default.
- W4255936150 hasLocation W42559361502 @default.
- W4255936150 hasOpenAccess W4255936150 @default.
- W4255936150 hasPrimaryLocation W42559361501 @default.
- W4255936150 hasRelatedWork W1974148029 @default.
- W4255936150 hasRelatedWork W2037685764 @default.
- W4255936150 hasRelatedWork W2056192651 @default.
- W4255936150 hasRelatedWork W2060319810 @default.
- W4255936150 hasRelatedWork W2060516282 @default.
- W4255936150 hasRelatedWork W2063972305 @default.
- W4255936150 hasRelatedWork W2067172377 @default.
- W4255936150 hasRelatedWork W2080498417 @default.
- W4255936150 hasRelatedWork W2092034319 @default.
- W4255936150 hasRelatedWork W2110444056 @default.
- W4255936150 hasVolume "62" @default.
- W4255936150 isParatext "false" @default.
- W4255936150 isRetracted "false" @default.
- W4255936150 workType "article" @default.