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• W4255996852 abstract "People can ingest soluble nickel compounds as a normal constituent of food or as a contaminant in drinking water. This paper presents an assessment of the noncancer and cancer human health risks from ingestion of soluble nickel compounds. A reference dose (RfD) of 8 x 10(-3) mg Ni/kg/day in addition to the amount in food was calculated, based on albuminuria in female rats exposed to nickel sulfate in drinking water for 6 months (A. Vyskocil et al., 1994, Hum. Exp. Toxicol. 13, 689-693). This RfD is comparable to the current RfD based on decreased body weight in a chronic feeding study in rats (A. M. Ambrose et al., 1976, J. Food Sci. Technol. 13, 181-187). The potential for nickel-induced reproductive toxicity was also taken into account in the derivation of the RfD. There are a number of negative animal bioassays with soluble nickel salts, but all of them have deficiencies that preclude a definitive conclusion. According to EPA's 1996 draft cancer guidelines, the carcinogenic potential of oral exposure to soluble nickel cannot be determined because there are inadequate data to perform an assessment." @default.
• W4255996852 created "2022-05-12" @default.
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• W4255996852 date "2000-04-01" @default.
• W4255996852 modified "2023-10-09" @default.
• W4255996852 title "Hazard Identification and Dose Response of Ingested Nickel-Soluble Salts" @default.
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• W4255996852 doi "https://doi.org/10.1006/rtph.2000.1378" @default.
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