Matches in SemOpenAlex for { <https://semopenalex.org/work/W4255998639> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4255998639 endingPage "S499" @default.
- W4255998639 startingPage "S499" @default.
- W4255998639 abstract "Many children with pervasive developmental disorders (PDDs) have serious, functionally impairing behavioral problems. We tested whether combined treatment (COMB) with risperidone and parent training (PT) in behavior management is superior to medication alone (MED) in improving severe behavioral problems in children with PDDs.This 24-week, three-site, randomized, parallel-groups clinical trial enrolled 124 children, aged 4 through 13 years, with PDDs, accompanied by frequent tantrums, self-injury, and aggression. The children were randomized 3:2 to COMB (n = 75) or MED (n = 49). The participants received risperidone monotherapy from 0.5 to 3.5 mg/day (with switch to aripiprazole if risperidone was ineffective). Parents in the COMB group (n = 75; 60.5%) received a mean of 10.9 PT sessions. The primary measure of compliance was the Home Situations Questionnaire (HSQ) score.Primary: intent-to-treat random effects regression showed that COMB was superior to MED on HSQ (p = .006) [effect size at week 24 (d) = 0.34]. The HSQ score declined from 4.31 (±1.67) to 1.23 (±1.36) for COMB compared with 4.16 (±1.47) to 1.68 (±1.36) for MED. Secondary: groups did not differ on Clinical Global Impressions–Improvement scores at endpoint; compared with MED, COMB showed significant reductions on Aberrant Behavior Checklist Irritability (d = 0.48; p = .01), Stereotypic Behavior (d = 0.23; p = .04), and Hyperactivity/Noncompliance subscales (d = 0.55; p = .04). Final risperidone mean dose for MED was 2.26 mg/day (0.071 mg/kg), compared with 1.98 mg/day for COMB (0.066 mg/kg) (p = .04).Medication plus PT resulted in greater reduction of serious maladaptive behavior than MED in children with PDDs, with a lower risperidone dose." @default.
- W4255998639 created "2022-05-12" @default.
- W4255998639 date "2005-01-01" @default.
- W4255998639 modified "2023-09-24" @default.
- W4255998639 title "P.3.100 Could a psychoeducational program reduce relapses in schizophrenic patients" @default.
- W4255998639 doi "https://doi.org/10.1016/s0924-977x(05)81036-3" @default.
- W4255998639 hasPublicationYear "2005" @default.
- W4255998639 type Work @default.
- W4255998639 citedByCount "0" @default.
- W4255998639 crossrefType "journal-article" @default.
- W4255998639 hasConcept C118552586 @default.
- W4255998639 hasConcept C126322002 @default.
- W4255998639 hasConcept C15744967 @default.
- W4255998639 hasConcept C168563851 @default.
- W4255998639 hasConcept C169900460 @default.
- W4255998639 hasConcept C187212893 @default.
- W4255998639 hasConcept C2776412080 @default.
- W4255998639 hasConcept C2780057945 @default.
- W4255998639 hasConcept C2780211496 @default.
- W4255998639 hasConcept C2780820931 @default.
- W4255998639 hasConcept C71924100 @default.
- W4255998639 hasConceptScore W4255998639C118552586 @default.
- W4255998639 hasConceptScore W4255998639C126322002 @default.
- W4255998639 hasConceptScore W4255998639C15744967 @default.
- W4255998639 hasConceptScore W4255998639C168563851 @default.
- W4255998639 hasConceptScore W4255998639C169900460 @default.
- W4255998639 hasConceptScore W4255998639C187212893 @default.
- W4255998639 hasConceptScore W4255998639C2776412080 @default.
- W4255998639 hasConceptScore W4255998639C2780057945 @default.
- W4255998639 hasConceptScore W4255998639C2780211496 @default.
- W4255998639 hasConceptScore W4255998639C2780820931 @default.
- W4255998639 hasConceptScore W4255998639C71924100 @default.
- W4255998639 hasLocation W42559986391 @default.
- W4255998639 hasOpenAccess W4255998639 @default.
- W4255998639 hasPrimaryLocation W42559986391 @default.
- W4255998639 hasRelatedWork W121176866 @default.
- W4255998639 hasRelatedWork W1838151939 @default.
- W4255998639 hasRelatedWork W1982932776 @default.
- W4255998639 hasRelatedWork W1999630630 @default.
- W4255998639 hasRelatedWork W2036794893 @default.
- W4255998639 hasRelatedWork W2083931142 @default.
- W4255998639 hasRelatedWork W2209305649 @default.
- W4255998639 hasRelatedWork W2732965635 @default.
- W4255998639 hasRelatedWork W2911380759 @default.
- W4255998639 hasRelatedWork W3157872865 @default.
- W4255998639 hasVolume "15" @default.
- W4255998639 isParatext "false" @default.
- W4255998639 isRetracted "false" @default.
- W4255998639 workType "article" @default.