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• W4256018868 abstract "(Mol Ther Nucleic Acids. 12, 478–489; September 7, 2018) The authors have discovered that the original article has errors in Figures 1, 2, and S1 that were introduced when a graduate student used the wrong shared image folder when putting together the figures. In the original Figure 1B, which shows expression of dystrophin-positive fibers in body-wide muscles, control images for wild-type C57 (TA and abdominal) and untreated mdx mice were repeatedly used instead of the right images corresponding to the mice used for this manuscript. The control images have been replaced and a corrected Figure 1B appears below. In the original Figure 2A, which shows expression of dystrophin-associated protein complex in quadriceps, the C57 control images were shown at the wrong magnification. The control images have been replaced and a corrected Figure 2A appears below. In the original Figure S1B, which shows histological staining of kidney and liver, the image for wild-type C57 (kidney) control was repeatedly used instead of the right images corresponding to the mice used for this manuscript. A corrected Figure S1B appears below. These corrections do not change the conclusions of the paper. The authors apologize for the errors and any confusion they may have caused.Figure 2Functional Improvement in mdx Mice Treated with PMO-GF for 1 Year.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Supplementary Figure 1Examination of body-weight and pathophysiological changes of mdx mice treated with PMO-GF for one year.View Large Image Figure ViewerDownload Hi-res image Download (PPT) Long-Term Morpholino Oligomers in Hexose Elicit Long-Lasting Therapeutic Improvements in mdx MiceHan et al.Molecular Therapy - Nucleic AcidsJune 21, 2018In BriefApproval of antisense oligonucleotide eteplirsen highlights the promise of exon-skipping therapeutics for Duchenne muscular dystrophy patients. However, the limited efficacy of eteplirsen underscores the importance to improve systemic delivery and efficacy. Recently, we demonstrated that a glucose and fructose (GF) delivery formulation effectively potentiates phosphorodiamidate morpholino oligomer (PMO). Considering the clinical potential of GF, it is important to determine the long-term compatibility and efficacy with PMO in mdx mice prior to clinical translation. Full-Text PDF Open Access" @default.
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• W4256018868 date "2020-12-01" @default.
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• W4256018868 title "Long-Term Morpholino Oligomers in Hexose Elicit Long-Lasting Therapeutic Improvements in mdx Mice" @default.
• W4256018868 doi "https://doi.org/10.1016/j.omtn.2020.09.005" @default.
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