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- W4256026145 abstract "Pellicularia filamentosa f.s. microsclerotia which is known to effect 19-hydroxylation of cortexolone has converted 17α, 20α, 21-trihydroxypregn-4-en-3-one into 17α, 19, 20α, 21-tetrahydroxypregn- 4-en-3-one and 11β, 17α, 20α, 21-tetrahydroxypregn-4-en-3-one with conversion ratios of one to four and one to seven, respectively while the microorganism mainly converted hydrocortisone into a reduced product, 11β, 17α, 20β, 21-tetrahydroxypregn-4-en-3-one with a small conversion ratio. As a result it has been concluded that 19- and 11β-hydroxylation catalyzed by the microorganism are hardly affected by a slight difference at the side chain of substrates but the 19-hydroxylation is almost completely prevented by the presence of a hydroxyl group at the 11β-position." @default.
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- W4256026145 date "1963-01-01" @default.
- W4256026145 modified "2023-10-01" @default.
- W4256026145 title "Studies on the Microbiological Transformations of Steroids" @default.
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- W4256026145 doi "https://doi.org/10.1271/bbb1961.27.639" @default.
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