Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256036280> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4256036280 endingPage "592" @default.
- W4256036280 startingPage "586" @default.
- W4256036280 abstract "Resistance to multiple chemotherapeutic agents has been related to the production of P-glycoprotein, a trans-membrane drug efflux pump that is encoded by the multidrug resistance (MDR) gene mdr1. To investigate whether mdr1 could be involved in clinical resistance to chemotherapy in acute leukemias, we have analyzed retrospectively the RNA from adult acute leukemia cells by slot-blot hybridization with a human mdr1 probe. Units of mdr1 expression were defined by reference to drug- sensitive human sarcoma and K562 leukemia cell lines (1 U) and the highly resistant doxorubicin selected leukemia cells K562/R7 (50 U). We studied 41 adult patients with acute leukemias: 5 acute lymphoblastic leukemias, 23 acute myeloid leukemias, and 13 secondary leukemias or blast crisis of chronic myelogenous leukemia. Expression of 10 U or more of mdr1 was found in 6 of 31 (19%) leukemias at diagnosis, versus 5 of 10 (50%) after relapse from therapy, P = .06. The complete remission rate and in vitro sensitivity to daunorubicin were both correlated with low expression (1 U, v 2 U or more) of mdr1. Among 36 evaluable attempts to induce remission, the complete remission rate was 67% (8 of 12) for patients with undetectable or minimal mdr1 expression (1 U), versus 29% (7 of 24) in patients with 2 U or more of expression, P = .03. In vitro resistance to daunorubicin or other MDR-related drugs was associated with expression of 2 U or more of mdr1 in 11 of 11 cases, while specimens that were sensitive to these agents were negative for mdr1 expression in 5 of 11 cases, P = .03. These data suggest that mdr1 expression contributes to chemoresistance in acute leukemia. Determination of mdr1 gene expression may be useful in designing therapy for patients with leukemia." @default.
- W4256036280 created "2022-05-12" @default.
- W4256036280 creator A5057651992 @default.
- W4256036280 creator A5064052433 @default.
- W4256036280 creator A5078885918 @default.
- W4256036280 date "1991-08-01" @default.
- W4256036280 modified "2023-09-29" @default.
- W4256036280 title "Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity" @default.
- W4256036280 doi "https://doi.org/10.1182/blood.v78.3.586.bloodjournal783586" @default.
- W4256036280 hasPublicationYear "1991" @default.
- W4256036280 type Work @default.
- W4256036280 citedByCount "8" @default.
- W4256036280 countsByYear W42560362802021 @default.
- W4256036280 crossrefType "journal-article" @default.
- W4256036280 hasAuthorship W4256036280A5057651992 @default.
- W4256036280 hasAuthorship W4256036280A5064052433 @default.
- W4256036280 hasAuthorship W4256036280A5078885918 @default.
- W4256036280 hasBestOaLocation W42560362801 @default.
- W4256036280 hasConcept C114851261 @default.
- W4256036280 hasConcept C126322002 @default.
- W4256036280 hasConcept C133936738 @default.
- W4256036280 hasConcept C171122931 @default.
- W4256036280 hasConcept C203014093 @default.
- W4256036280 hasConcept C2776694085 @default.
- W4256036280 hasConcept C2776863199 @default.
- W4256036280 hasConcept C2778041864 @default.
- W4256036280 hasConcept C2778461978 @default.
- W4256036280 hasConcept C2778707650 @default.
- W4256036280 hasConcept C2781021840 @default.
- W4256036280 hasConcept C2781303535 @default.
- W4256036280 hasConcept C502942594 @default.
- W4256036280 hasConcept C54355233 @default.
- W4256036280 hasConcept C71924100 @default.
- W4256036280 hasConcept C86803240 @default.
- W4256036280 hasConcept C98274493 @default.
- W4256036280 hasConceptScore W4256036280C114851261 @default.
- W4256036280 hasConceptScore W4256036280C126322002 @default.
- W4256036280 hasConceptScore W4256036280C133936738 @default.
- W4256036280 hasConceptScore W4256036280C171122931 @default.
- W4256036280 hasConceptScore W4256036280C203014093 @default.
- W4256036280 hasConceptScore W4256036280C2776694085 @default.
- W4256036280 hasConceptScore W4256036280C2776863199 @default.
- W4256036280 hasConceptScore W4256036280C2778041864 @default.
- W4256036280 hasConceptScore W4256036280C2778461978 @default.
- W4256036280 hasConceptScore W4256036280C2778707650 @default.
- W4256036280 hasConceptScore W4256036280C2781021840 @default.
- W4256036280 hasConceptScore W4256036280C2781303535 @default.
- W4256036280 hasConceptScore W4256036280C502942594 @default.
- W4256036280 hasConceptScore W4256036280C54355233 @default.
- W4256036280 hasConceptScore W4256036280C71924100 @default.
- W4256036280 hasConceptScore W4256036280C86803240 @default.
- W4256036280 hasConceptScore W4256036280C98274493 @default.
- W4256036280 hasIssue "3" @default.
- W4256036280 hasLocation W42560362801 @default.
- W4256036280 hasOpenAccess W4256036280 @default.
- W4256036280 hasPrimaryLocation W42560362801 @default.
- W4256036280 hasRelatedWork W10835008 @default.
- W4256036280 hasRelatedWork W10962344 @default.
- W4256036280 hasRelatedWork W13950329 @default.
- W4256036280 hasRelatedWork W14536495 @default.
- W4256036280 hasRelatedWork W17235185 @default.
- W4256036280 hasRelatedWork W2855694 @default.
- W4256036280 hasRelatedWork W3093886 @default.
- W4256036280 hasRelatedWork W3598312 @default.
- W4256036280 hasRelatedWork W4479156 @default.
- W4256036280 hasRelatedWork W6670230 @default.
- W4256036280 hasVolume "78" @default.
- W4256036280 isParatext "false" @default.
- W4256036280 isRetracted "false" @default.
- W4256036280 workType "article" @default.