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- W4256084588 abstract "The clinical usefulness of measuring specific enzyme levels in serum is well established. Depending on the enzyme being studied, quantitative elevation in the serum is a relatively sensitive indication that tissue damage has occurred. However, such quantitative measurements fail to demonstrate the specific tissue involved, and in the case of the total lactic dehydrogenase (LDH) determination, elevated serum levels may be seen in a number of clinical conditions. Because enzymes occur in multiple molecular forms called<i>isoenzymes</i>or<i>isozymes</i>which have similar biologic activity, they may be distinguished by electrophoretic techniques. Electrophoresis separates LDH into its constituent isoenzymes and provides the physician with organ-specific information because the proportion of these individual isoenzymes varies in different organs. Identification of isoenzymes is of additional value since there may be diagnostically significant changes in the isoenzyme patterns (zymograms) without any change in the total serum level." @default.
- W4256084588 created "2022-05-12" @default.
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- W4256084588 date "1968-07-29" @default.
- W4256084588 modified "2023-09-27" @default.
- W4256084588 title "Lactic dehydrogenase isoenzyme electrophoresis" @default.
- W4256084588 doi "https://doi.org/10.1001/jama.205.5.294" @default.
- W4256084588 hasPublicationYear "1968" @default.
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