FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256102557> ?p ?o ?g. }

• W4256102557 endingPage "180" @default.
• W4256102557 startingPage "174" @default.
• W4256102557 abstract "We studied the effects of ketamine and propofol on two ligand-gated ion channels mediating fast synaptic transmission through sympathetic ganglia, neuronal nicotinic acetylcholine receptors (nAchRs), and P2x purinoceptors in a rat pheochromocytoma cell line PC12 using whole cell voltage clamp recording. Ketamine and propofol similarly inhibited the nicotine-induced inward current reversibly and dosedependently at the membrane potential of -60 mV but had no effects on the adenosine triphosphate-induced current. Both anesthetics accelerated the current decay during agonist application, resulting in greater inhibition on the steady current than the peak current. The 50% inhibition concentration values for the steady current were lower than the clinically relevant concentrations for ketamine (2.8 +/- 0.6 [micro sign]M) and higher than those for propofol (5.4 +/- 0.6 [micro sign]M). Both anesthetics induced an addition of the fast component to the decay phase and an acceleration of the slow component, which suggests an open channel blockade or an enhancement of desensitization as a mechanism. The effects on closed channels seemed to be small because preincubation with the anesthetics did not significantly augment the block. Inhibition was voltage-independent at membrane potentials between -20 and -70 mV and was consistent with a noncompetitive block. Inhibition of the neuronal nAchR-mediated current may lead to the suppression of synaptic transmission in sympathetic ganglia by ketamine, but not by propofol, at the clinically relevant concentrations. However, these results are not consistent with changes in sympathetic nerve activities reported for animals or humans anesthetized with ketamine or propofol, which suggests effects from other systems, such as the central nervous system in vivo. Implications: Ketamine (at smaller than clinically relevant concentrations) and propofol (at larger than clinically relevant concentrations) inhibited neuronal nicotinic acetylcholine receptor-mediated current in PC12 cells, which possess the receptors that resemble those in postganglionic sympathetic neurons. These findings are not consistent with in vivo experiments, which suggests that effects from other systems, such as the central nervous system, are of importance. (Anesth Analg 1999;88:174-80)" @default.
• W4256102557 created "2022-05-12" @default.
• W4256102557 creator A5033227685 @default.
• W4256102557 creator A5041119102 @default.
• W4256102557 creator A5049962483 @default.
• W4256102557 creator A5067636946 @default.
• W4256102557 creator A5071626594 @default.
• W4256102557 creator A5073196141 @default.
• W4256102557 date "1999-01-01" @default.
• W4256102557 modified "2023-10-18" @default.
• W4256102557 title "The Effects of Ketamine and Propofol on Neuronal Nicotinic Acetylcholine Receptors and P2x Purinoceptors in PC12 Cells" @default.
• W4256102557 cites W1499547922 @default.
• W4256102557 cites W1607927414 @default.
• W4256102557 cites W1652413561 @default.
• W4256102557 cites W1966844562 @default.
• W4256102557 cites W1976885068 @default.
• W4256102557 cites W1981463658 @default.
• W4256102557 cites W1995709572 @default.
• W4256102557 cites W1996449721 @default.
• W4256102557 cites W1997990428 @default.
• W4256102557 cites W2007999249 @default.
• W4256102557 cites W2009667219 @default.
• W4256102557 cites W2012817638 @default.
• W4256102557 cites W2015290558 @default.
• W4256102557 cites W2019439632 @default.
• W4256102557 cites W2026431577 @default.
• W4256102557 cites W2027817574 @default.
• W4256102557 cites W2030293146 @default.
• W4256102557 cites W2064605769 @default.
• W4256102557 cites W2072606072 @default.
• W4256102557 cites W2081025398 @default.
• W4256102557 cites W2081391428 @default.
• W4256102557 cites W2082055276 @default.
• W4256102557 cites W2086792418 @default.
• W4256102557 cites W4243447250 @default.
• W4256102557 doi "https://doi.org/10.1213/00000539-199901000-00033" @default.
• W4256102557 hasPublicationYear "1999" @default.
• W4256102557 type Work @default.
• W4256102557 citedByCount "37" @default.
• W4256102557 countsByYear W42561025572012 @default.
• W4256102557 countsByYear W42561025572013 @default.
• W4256102557 countsByYear W42561025572015 @default.
• W4256102557 countsByYear W42561025572016 @default.
• W4256102557 countsByYear W42561025572018 @default.
• W4256102557 countsByYear W42561025572020 @default.
• W4256102557 countsByYear W42561025572022 @default.
• W4256102557 countsByYear W42561025572023 @default.
• W4256102557 crossrefType "journal-article" @default.
• W4256102557 hasAuthorship W4256102557A5033227685 @default.
• W4256102557 hasAuthorship W4256102557A5041119102 @default.
• W4256102557 hasAuthorship W4256102557A5049962483 @default.
• W4256102557 hasAuthorship W4256102557A5067636946 @default.
• W4256102557 hasAuthorship W4256102557A5071626594 @default.
• W4256102557 hasAuthorship W4256102557A5073196141 @default.
• W4256102557 hasBestOaLocation W42561025571 @default.
• W4256102557 hasConcept C12554922 @default.
• W4256102557 hasConcept C126322002 @default.
• W4256102557 hasConcept C134018914 @default.
• W4256102557 hasConcept C147944092 @default.
• W4256102557 hasConcept C169760540 @default.
• W4256102557 hasConcept C170493617 @default.
• W4256102557 hasConcept C188987157 @default.
• W4256102557 hasConcept C200170125 @default.
• W4256102557 hasConcept C2775910092 @default.
• W4256102557 hasConcept C2776277131 @default.
• W4256102557 hasConcept C2776991684 @default.
• W4256102557 hasConcept C2778938600 @default.
• W4256102557 hasConcept C2780795376 @default.
• W4256102557 hasConcept C42219234 @default.
• W4256102557 hasConcept C71924100 @default.
• W4256102557 hasConcept C80161118 @default.
• W4256102557 hasConcept C86803240 @default.
• W4256102557 hasConcept C98274493 @default.
• W4256102557 hasConceptScore W4256102557C12554922 @default.
• W4256102557 hasConceptScore W4256102557C126322002 @default.
• W4256102557 hasConceptScore W4256102557C134018914 @default.
• W4256102557 hasConceptScore W4256102557C147944092 @default.
• W4256102557 hasConceptScore W4256102557C169760540 @default.
• W4256102557 hasConceptScore W4256102557C170493617 @default.
• W4256102557 hasConceptScore W4256102557C188987157 @default.
• W4256102557 hasConceptScore W4256102557C200170125 @default.
• W4256102557 hasConceptScore W4256102557C2775910092 @default.
• W4256102557 hasConceptScore W4256102557C2776277131 @default.
• W4256102557 hasConceptScore W4256102557C2776991684 @default.
• W4256102557 hasConceptScore W4256102557C2778938600 @default.
• W4256102557 hasConceptScore W4256102557C2780795376 @default.
• W4256102557 hasConceptScore W4256102557C42219234 @default.
• W4256102557 hasConceptScore W4256102557C71924100 @default.
• W4256102557 hasConceptScore W4256102557C80161118 @default.
• W4256102557 hasConceptScore W4256102557C86803240 @default.
• W4256102557 hasConceptScore W4256102557C98274493 @default.
• W4256102557 hasIssue "1" @default.
• W4256102557 hasLocation W42561025571 @default.
• W4256102557 hasLocation W42561025572 @default.
• W4256102557 hasOpenAccess W4256102557 @default.
• W4256102557 hasPrimaryLocation W42561025571 @default.
• W4256102557 hasRelatedWork W1570361834 @default.
• W4256102557 hasRelatedWork W1981881599 @default.

• next