Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256102690> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4256102690 abstract "Abstract Background The potential risk for cognitive impairment following surgery and anesthesia is a common concern, especially in the elderly and more fragile patient. The risk for various neurocognitive effects is thus an area of importance. The independent impact of surgery and anesthesia is still not known. Likewise, the independent effect of different drugs used during anesthesia is a matter of debate as is the number and amounts of drugs used and the depth of anesthesia. So, understanding the drug-related phenomenon and mechanisms for postoperative cognitive impairment is essential. This meta-analysis aims to compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function in elderly patients with lung cancer. Methods This study is a systematic review and meta-analysis for controlled clinical studies. Public-available online databases were searched to identify eligible randomized placebo-controlled trials or prospective cohort studies concerning the effects of propofol and sevoflurane on postoperative cognitive function. The primary endpoints are postoperative mini-mental state examination (MMSE) scores at various time points; the secondary endpoint is the serum S100beta concentration 24 hours after surgery. SMDs along with 95% CIs were extracted and analyzed using random or fixed effects models. Analyses regarding heterogeneity, risk of bias assessment, and sensitivity were performed. Results We searched 1626 eligible publications and 14 studies of 1404 patients were included in the final analysis. The majority of included studies had been undertaken in Asian populations. Results suggested that propofol has a greater adverse effect on cognitive function in the elderly patients with lung cancer than sevoflurane. There were significant differences in issues of MMSE 6h (11 studies; SMD -1.391, 95% CI -2.024, -0.757; p < 0.001), MMSE 24h (14 studies; SMD -1.106, 95% CI -1.588, -0.624; p < 0.001), MMSE 3d (11 studies; SMD -1.065, 95% CI -1.564, -0.566; p < 0.001), MMSE 7d (10 studies; SMD -0.422, 95% CI -0.549, -0.295; p < 0.001), and serum S100beta concentration at 1 day after surgery (13 studies; SMD 0.746, 95% CI 0.475, 1.017; p < 0.001). Conclusion Propofol has a more significant adverse effect on postoperative cognitive function in elderly patients with lung cancer than sevoflurane." @default.
- W4256102690 created "2022-05-12" @default.
- W4256102690 creator A5000597313 @default.
- W4256102690 creator A5005810389 @default.
- W4256102690 creator A5014450924 @default.
- W4256102690 creator A5017562812 @default.
- W4256102690 creator A5039084091 @default.
- W4256102690 creator A5069994888 @default.
- W4256102690 creator A5081728631 @default.
- W4256102690 creator A5088070856 @default.
- W4256102690 date "2019-08-09" @default.
- W4256102690 modified "2023-10-16" @default.
- W4256102690 title "Comparative Analysis of the Effects of Propofol and Sevoflurane on Postoperative Cognitive Function in Elderly Patients with Lung Cancer" @default.
- W4256102690 doi "https://doi.org/10.21203/rs.2.12568/v1" @default.
- W4256102690 hasPublicationYear "2019" @default.
- W4256102690 type Work @default.
- W4256102690 citedByCount "0" @default.
- W4256102690 crossrefType "posted-content" @default.
- W4256102690 hasAuthorship W4256102690A5000597313 @default.
- W4256102690 hasAuthorship W4256102690A5005810389 @default.
- W4256102690 hasAuthorship W4256102690A5014450924 @default.
- W4256102690 hasAuthorship W4256102690A5017562812 @default.
- W4256102690 hasAuthorship W4256102690A5039084091 @default.
- W4256102690 hasAuthorship W4256102690A5069994888 @default.
- W4256102690 hasAuthorship W4256102690A5081728631 @default.
- W4256102690 hasAuthorship W4256102690A5088070856 @default.
- W4256102690 hasBestOaLocation W42561026901 @default.
- W4256102690 hasConcept C118552586 @default.
- W4256102690 hasConcept C126322002 @default.
- W4256102690 hasConcept C142724271 @default.
- W4256102690 hasConcept C143998085 @default.
- W4256102690 hasConcept C169900460 @default.
- W4256102690 hasConcept C172467417 @default.
- W4256102690 hasConcept C197934379 @default.
- W4256102690 hasConcept C204787440 @default.
- W4256102690 hasConcept C27081682 @default.
- W4256102690 hasConcept C2776256026 @default.
- W4256102690 hasConcept C2776277131 @default.
- W4256102690 hasConcept C2778078201 @default.
- W4256102690 hasConcept C2781453256 @default.
- W4256102690 hasConcept C42219234 @default.
- W4256102690 hasConcept C71924100 @default.
- W4256102690 hasConcept C95190672 @default.
- W4256102690 hasConceptScore W4256102690C118552586 @default.
- W4256102690 hasConceptScore W4256102690C126322002 @default.
- W4256102690 hasConceptScore W4256102690C142724271 @default.
- W4256102690 hasConceptScore W4256102690C143998085 @default.
- W4256102690 hasConceptScore W4256102690C169900460 @default.
- W4256102690 hasConceptScore W4256102690C172467417 @default.
- W4256102690 hasConceptScore W4256102690C197934379 @default.
- W4256102690 hasConceptScore W4256102690C204787440 @default.
- W4256102690 hasConceptScore W4256102690C27081682 @default.
- W4256102690 hasConceptScore W4256102690C2776256026 @default.
- W4256102690 hasConceptScore W4256102690C2776277131 @default.
- W4256102690 hasConceptScore W4256102690C2778078201 @default.
- W4256102690 hasConceptScore W4256102690C2781453256 @default.
- W4256102690 hasConceptScore W4256102690C42219234 @default.
- W4256102690 hasConceptScore W4256102690C71924100 @default.
- W4256102690 hasConceptScore W4256102690C95190672 @default.
- W4256102690 hasLocation W42561026901 @default.
- W4256102690 hasLocation W42561026902 @default.
- W4256102690 hasLocation W42561026903 @default.
- W4256102690 hasOpenAccess W4256102690 @default.
- W4256102690 hasPrimaryLocation W42561026901 @default.
- W4256102690 hasRelatedWork W2058081428 @default.
- W4256102690 hasRelatedWork W2270150298 @default.
- W4256102690 hasRelatedWork W2401023030 @default.
- W4256102690 hasRelatedWork W2793143924 @default.
- W4256102690 hasRelatedWork W2901519750 @default.
- W4256102690 hasRelatedWork W2918118040 @default.
- W4256102690 hasRelatedWork W3030434109 @default.
- W4256102690 hasRelatedWork W3119643299 @default.
- W4256102690 hasRelatedWork W4221091279 @default.
- W4256102690 hasRelatedWork W563456721 @default.
- W4256102690 isParatext "false" @default.
- W4256102690 isRetracted "false" @default.
- W4256102690 workType "article" @default.