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- W4256133725 abstract "This chapter describes the adverse effects of antihistamines. Sedation is regarded as a common adverse effect of most antihistamines (H1-receptor antagonists). Psychometric tests allow a sensitive rating of central nervous system depression, but the selection of an appropriate method for evaluation depends on the number of patients and related costs. The risk of central nervous system adverse effects associated with antihistamines is significant with the first-generation antihistamines, which have effects on serotonergic, α-adrenergic, dopaminergic, and muscarinic cholinergic pathways. The adverse effects of first generation antihistamines most often include drowsiness, fatigue, and an inability to concentrate. Continuous or long-term dosing of the second-generation (non-sedating) H1-receptor antagonists is thought to increase the likelihood of brain exposure, and it is also postulated that lower lipid solubility merely slows the rate of drug uptake. Moreover, these drugs may have effects at CNS receptor sites other than histamine receptors, and sedation may also result from interaction with other central neurotransmitter receptors." @default.
- W4256133725 created "2022-05-12" @default.
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- W4256133725 date "1998-01-01" @default.
- W4256133725 modified "2023-09-30" @default.
- W4256133725 title "Antihistamines" @default.
- W4256133725 doi "https://doi.org/10.1016/s0378-6080(98)80019-6" @default.
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