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• W4256149052 abstract "<h3>Background</h3> Platelet derived chemokines, such as PF-4 and its nonallelic variant PF-4var, are implicated in several aspects of thrombosis and inflammation. Previous study from our group demonstrates a novel interaction between β2-glycoprotein I (β2GPI) and PF-4 or PF-4var. <h3>Objectives</h3> To determine PF-4var plasma levels and platelet PF-4var expression (RNA level) in patients with APS and evaluate the correlation with clinical and laboratory parameters of the disease. <h3>Methods</h3> From 90 patients, who fulfill the revised diagnostic criteria for APS, blood samples were taken and separate samples of serum, plasma and platelets were isolated. A healthy control (n=55) and a disease control group (SLE, n=30) were included in the study. Plasma levels of PF-4var were determined using an ELISA, which absolutely discriminates PF-4var from PF-4. Platelet PF-4var and PF4 RNA levels were determined in RNA isolated from platelet preparations using RT-PCR. <h3>Results</h3> APS patients showed higher levels of plasma PF-4var compared to healthy individuals or SLE patients (APS: median 137.4 pg/ml; intarquartile range 65.69-219.2 pg/ml versus HD: 60.52 [36.04-97.12] pg/ml, p<0.0001 or SLE: 51.20 [16.37-172.9] pg/ml, p=0.0027). In addition, RT-PCR revealed significantly higher PF-4var expression in platelets derived from APS patients comparing to healthy donors or lupus patients (2^-ΔΔCT: APS: 1.461; [0.6743-2.796] versus HD: 0.815 [0.4260-1.132], p=0.0020 or SLE: 0.7505 [0.4790-1.136] p=0.0017). PF-4var levels were significantly elevated in patients with primary APS than those with APS secondary to SLE [p=0.0086]. Regarding the clinical presentation of the disease, patients who experienced thrombotic events versus pregnancy morbidity or arterial versus venous thrombotic events do not show statistically significant difference in PF-4var levels. A positive correlation was revealed between thrombocytopenia and elongation of aPTT with the higher PF-4var levels. <h3>Conclusions</h3> Preliminary results suggest that higher PF-4var levels are present in plasma of APS patients and especially in those with PAPS and these are associated with laboratory characteristics indicative for higher risk of thrombotic complications. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3696" @default.
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• W4256149052 date "2014-06-01" @default.
• W4256149052 modified "2023-10-18" @default.
• W4256149052 title "AB0183 Plasma Levels of PF-4VAR/CXCL4L1, A Non Allelic Variant of Platelet Factor-4 (PF-4/CXCL4), are Elevated in Patients with Antiphospholipid Syndrome (APS)" @default.
• W4256149052 doi "https://doi.org/10.1136/annrheumdis-2014-eular.3696" @default.
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