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- W4256165808 abstract "Abstract The detection of BCR-ABL1 mRNA transcripts is essential to molecular chronic myeloid leukemia (CML) diagnosis. In most cases, the RT-qPCR technique is performed as the gold standard diagnosis tool for clinical cases. However, this method requires expensive reagents and equipment, such as a real-time thermal cycler, probes and master mix. Consequently, the development and validation of simple and low-cost methods are essential for a rapid CML diagnosis in less specialized and equipped centers. In this study, we develop and demonstrate an accessible, rapid, and low-cost method using RT-LAMP for BCR-ABL1 detection in both cell lines and CML clinical samples, using colorimetric and fluorescent assays. Differently to the Q-LAMP assay described in 2019 by Stella and collaborators, the samples here were analyzed by RT-qPCR and the results were compared to the results obtained by fluorescent and colorimetric RT-LAMP. The obtained data indicates that the proposed method here described is a cheaper, robust and specific approach for CML diagnosis with outstanding performance." @default.
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- W4256165808 date "2021-07-20" @default.
- W4256165808 modified "2023-09-26" @default.
- W4256165808 title "Fluorescent and Colorimetric RT-LAMP as a Rapid and Specific Qualitative Method for Chronic Myeloid Leukemia Diagnosis" @default.
- W4256165808 doi "https://doi.org/10.21203/rs.3.rs-712437/v1" @default.
- W4256165808 hasPublicationYear "2021" @default.
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