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- W4256167475 abstract "Abstract Background This study explored relationships between low-/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in non-valvular atrial fibrillation (NVAF) patients in Xinjiang, which could provide a theoretical and therapeutic basis for patients with NVAF. Methods NVAF patients who were admitted to 10 medical centres across Xinjiang were divided into the stroke (798 patients) and control (2671 patients) groups according to whether acute IS occurred. Univariate and multivariate logistic regression analysis was used to examine the independent risk factors for IS in NVAF patients. We used factor analysis and principal component regression analysis to analyse the main influencing factors of IS. Receiver operating characteristic (ROC) curve analysis was used to evaluate the optimal cut-off value of LDL-C/HDL-C in predicting IS. Results Multivariate logistic regression showed that the risk of IS in the highest quartile of LDL-C/HDL-C (≥ 2.73) was 16.23-fold that in the lowest quartile (< 1.22); IS risk was 2.27-fold higher in obese patients (BMI ≥ 28 kg/m 2 ) than in normal-weight subjects; IS risk was 3.15-fold higher in smoking than in non-smoking patients. The area under the ROC curve of LDL-C/HDL-C was 0.76, optimal critical value was 2.33, sensitivity was 63.53%, and specificity was 76.34%. Principal component regression analysis showed that LDL-C/HDL-C, age, smoking, drinking, LDL-C and hypertension were risk factors for IS in NVAF patients. Conclusions LDL-C/HDL-C > 1.22, smoking and BMI ≥ 24 kg/m 2 were independent risk factors for IS in NVAF patients, of which LDL-C/HDL-C was the main risk factor." @default.
- W4256167475 created "2022-05-12" @default.
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- W4256167475 date "2020-08-18" @default.
- W4256167475 modified "2023-10-17" @default.
- W4256167475 title "LDL-C/HDL-C is Associated With Ischaemic Stroke in Patients With Non-Valvular Atrial Fibrillation: A Case-Control Study" @default.
- W4256167475 doi "https://doi.org/10.21203/rs.3.rs-60899/v1" @default.
- W4256167475 hasPublicationYear "2020" @default.
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