Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256167480> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4256167480 abstract "HIV-1 envelope glycoproteins (Env), expressed at the cell surface, induce apoptosis of uninfected CD4+ T cells, contributing to the development of AIDS. Here we demonstrate that, independently of HIV replication, transfected or HIV-infected cells that express Env induced autophagy and accumulation of Beclin 1 in uninfected CD4+ T lymphocytes via CXCR4. The same phenomena occurred in a T cell line and in transfected HEK.293 cells that expressed both wild-type CXCR4 and a truncated form of CD4 that is unable to bind the lymphocyte-specific protein kinase Lck. Env-mediated autophagy is required to trigger CD4+ T cell apoptosis since blockade of autophagy at different steps, by either drugs (3-methyladenine and bafilomycin A1) or siRNAs specific for Beclin 1/Atg6 and Atg7 genes, totally inhibited the apoptotic process. Furthermore, CD4+ T cells still underwent Env-mediated cell death with autophagic features when apoptosis was inhibited. These results suggest that HIV-infected cells can induce autophagy in bystander CD4+ T lymphocytes through contact of Env with CXCR4, leading to apoptotic cell death, a mechanism most likely contributing to immunodeficiency. PMID: 16886061" @default.
- W4256167480 created "2022-05-12" @default.
- W4256167480 creator A5045104926 @default.
- W4256167480 date "2006-08-11" @default.
- W4256167480 modified "2023-10-05" @default.
- W4256167480 title "Faculty Opinions recommendation of Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4." @default.
- W4256167480 doi "https://doi.org/10.3410/f.1033798.388969" @default.
- W4256167480 hasPublicationYear "2006" @default.
- W4256167480 type Work @default.
- W4256167480 citedByCount "0" @default.
- W4256167480 crossrefType "dataset" @default.
- W4256167480 hasAuthorship W4256167480A5045104926 @default.
- W4256167480 hasBestOaLocation W42561674801 @default.
- W4256167480 hasConcept C153911025 @default.
- W4256167480 hasConcept C159047783 @default.
- W4256167480 hasConcept C179464577 @default.
- W4256167480 hasConcept C185592680 @default.
- W4256167480 hasConcept C190283241 @default.
- W4256167480 hasConcept C203014093 @default.
- W4256167480 hasConcept C203522944 @default.
- W4256167480 hasConcept C22615655 @default.
- W4256167480 hasConcept C2776090121 @default.
- W4256167480 hasConcept C31573885 @default.
- W4256167480 hasConcept C54009773 @default.
- W4256167480 hasConcept C54355233 @default.
- W4256167480 hasConcept C81885089 @default.
- W4256167480 hasConcept C86803240 @default.
- W4256167480 hasConcept C8891405 @default.
- W4256167480 hasConcept C95444343 @default.
- W4256167480 hasConceptScore W4256167480C153911025 @default.
- W4256167480 hasConceptScore W4256167480C159047783 @default.
- W4256167480 hasConceptScore W4256167480C179464577 @default.
- W4256167480 hasConceptScore W4256167480C185592680 @default.
- W4256167480 hasConceptScore W4256167480C190283241 @default.
- W4256167480 hasConceptScore W4256167480C203014093 @default.
- W4256167480 hasConceptScore W4256167480C203522944 @default.
- W4256167480 hasConceptScore W4256167480C22615655 @default.
- W4256167480 hasConceptScore W4256167480C2776090121 @default.
- W4256167480 hasConceptScore W4256167480C31573885 @default.
- W4256167480 hasConceptScore W4256167480C54009773 @default.
- W4256167480 hasConceptScore W4256167480C54355233 @default.
- W4256167480 hasConceptScore W4256167480C81885089 @default.
- W4256167480 hasConceptScore W4256167480C86803240 @default.
- W4256167480 hasConceptScore W4256167480C8891405 @default.
- W4256167480 hasConceptScore W4256167480C95444343 @default.
- W4256167480 hasLocation W42561674801 @default.
- W4256167480 hasOpenAccess W4256167480 @default.
- W4256167480 hasPrimaryLocation W42561674801 @default.
- W4256167480 hasRelatedWork W2012224340 @default.
- W4256167480 hasRelatedWork W2084880710 @default.
- W4256167480 hasRelatedWork W2131274358 @default.
- W4256167480 hasRelatedWork W2350597139 @default.
- W4256167480 hasRelatedWork W2355246966 @default.
- W4256167480 hasRelatedWork W2383177540 @default.
- W4256167480 hasRelatedWork W2890156259 @default.
- W4256167480 hasRelatedWork W2912385559 @default.
- W4256167480 hasRelatedWork W2993499003 @default.
- W4256167480 hasRelatedWork W843168755 @default.
- W4256167480 isParatext "false" @default.
- W4256167480 isRetracted "false" @default.
- W4256167480 workType "dataset" @default.