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- W4256183346 abstract "The HRS Meeting was held in San Francisco, California, in May 2004. The meeting was well attended. The hot issue in basic science is the relation between intracellular calcium (Cai) dynamics and the mechanisms of cardiac arrhythmia. Rajawat et al (Heart Rhythm 2004;S5) developed a transgenic mouse of Andersen syndrome by overexpressing a mutant gene that encodes slow rectifying K channel (Kir2.1). The mouse developed bidirectional ventricular tachycardia, suggesting abnormalities of Cai dynamics. Tian et al (Heart Rhythm 2004;S5) developed a transgenic mouse with selective cardiac expression of a mutated sodium channel gene (SCN5A, N1325S). There was arrhythmia and up-regulated cardiac ryanodine receptor (RyR2) and down-regulated NaCaX in this model. The authors concluded that arrhythmogenic effects of gain of function mutation contribute to Cai imbalance, which in turn triggers lethal arrhythmias. These two studies are interesting because the mutations are in the K channel and in the Na channel, but the arrhythmogenesis is related to abnormal Cai dynamics. Miyoshi et al (Heart Rhythm 2004;S190) performed a computer simulation study of Brugada syndrome. Their results showed that the dispersion of ICaL density in the right ventricular epicardium can simulate the ECG changes associated with Brugada syndrome. The authors suggest that it is possible to develop Brugada syndrome without SCN5A mutation. This third study further highlights the possible importance of calcium dynamics in arrhythmogenesis. In addition to these mouse models and simulation studies, several invited speakers summarized the importance of Cai dynamics in cardiac arrhythmogenesis. For example, rapid heart rate can lead to Cai accumulation, which in turn might result in spontaneous (voltage-independent) calcium release and trigger ventricular arrhythmia. Others showed significant heterogeneity in the transmural distribution of calcium handling proteins. These changes may contribute to the electrical heterogeneity of the ventricles." @default.
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- W4256183346 date "2004-09-01" @default.
- W4256183346 modified "2023-10-16" @default.
- W4256183346 title "EP news" @default.
- W4256183346 doi "https://doi.org/10.1016/j.hrthm.2004.06.014" @default.
- W4256183346 hasPublicationYear "2004" @default.
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