Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256191831> ?p ?o ?g. }
Showing items 1 to 42 of
42
with 100 items per page.
- W4256191831 abstract "Degradable branched polycationic systems have exhibited exceptional potential for nucleic acid delivery due to their good responsive degradability and exceptional transfection efficacy. We focused on current work on the development of ARP for nucleic acid delivery in this study. The results of numerous responsive degradable branching polycationic systems were assembled. For the synthesis of ARP, the typical amino-epoxy ring-opening procedure was primarily presented. For nucleic acid delivery, the properties of redox- and pH-responsive degradable branching systems were addressed. Despite great development, there are still a lot of barriers to overcome in this discipline. The step growth strategy is more convenient than the chain growth technique. However, the polydispersity index (PDI) of most branched polymers generated by the step growth process is relatively high, making biological investigations hard. As a result, regulating the batch-to-batch quality of branched polycations is important for the translation of ARP from laboratories to clinics. Furthermore, as diseases develop more complicated and treatment processes get more diversified, single-function nucleic acid carriers are increasingly unable to satisfy complicated needs. Nucleic acid carriers must be manufactured in a precise and multifunctional method. In nucleic acid-based therapy, branched polycations must have degradability, targeting capability, and multimodal therapeutic properties in addition to degradability. In the future, one problem will be how to develop degradable, targeted, and multifunctional branching polycations for nucleic acid delivery in a regulated manner. Degradable branching polycationic systems will have a substantial effect on nucleic acid delivery and will become key instruments for nucleic acid treatment as research improves and allied areas such as materials science and medicine improve quickly." @default.
- W4256191831 created "2022-05-12" @default.
- W4256191831 creator A5016938750 @default.
- W4256191831 date "2021-06-15" @default.
- W4256191831 modified "2023-10-14" @default.
- W4256191831 title "Degradable branched polycationic systems are promising gene therapy vectors" @default.
- W4256191831 doi "https://doi.org/10.31219/osf.io/utypf" @default.
- W4256191831 hasPublicationYear "2021" @default.
- W4256191831 type Work @default.
- W4256191831 citedByCount "0" @default.
- W4256191831 crossrefType "posted-content" @default.
- W4256191831 hasAuthorship W4256191831A5016938750 @default.
- W4256191831 hasConcept C171250308 @default.
- W4256191831 hasConcept C178790620 @default.
- W4256191831 hasConcept C185592680 @default.
- W4256191831 hasConcept C192562407 @default.
- W4256191831 hasConcept C206175624 @default.
- W4256191831 hasConcept C24107716 @default.
- W4256191831 hasConcept C55493867 @default.
- W4256191831 hasConceptScore W4256191831C171250308 @default.
- W4256191831 hasConceptScore W4256191831C178790620 @default.
- W4256191831 hasConceptScore W4256191831C185592680 @default.
- W4256191831 hasConceptScore W4256191831C192562407 @default.
- W4256191831 hasConceptScore W4256191831C206175624 @default.
- W4256191831 hasConceptScore W4256191831C24107716 @default.
- W4256191831 hasConceptScore W4256191831C55493867 @default.
- W4256191831 hasLocation W42561918311 @default.
- W4256191831 hasOpenAccess W4256191831 @default.
- W4256191831 hasPrimaryLocation W42561918311 @default.
- W4256191831 hasRelatedWork W177218465 @default.
- W4256191831 hasRelatedWork W2012834822 @default.
- W4256191831 hasRelatedWork W2013246191 @default.
- W4256191831 hasRelatedWork W2037278905 @default.
- W4256191831 hasRelatedWork W2087313672 @default.
- W4256191831 hasRelatedWork W2139987833 @default.
- W4256191831 hasRelatedWork W2791048938 @default.
- W4256191831 hasRelatedWork W2909338915 @default.
- W4256191831 hasRelatedWork W2952317794 @default.
- W4256191831 hasRelatedWork W2461687825 @default.
- W4256191831 isParatext "false" @default.
- W4256191831 isRetracted "false" @default.
- W4256191831 workType "article" @default.