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- W4256292276 abstract "The transcription factor ETS-1 is induced in endothelial cells (ECs) by angiogenic growth factors and the specific elimination of ETS-1 synthesis by antisense oligodeoxynucleotide inhibited angiogenesis in vitro (Iwasaka et al., 1996, J Cell Physiol 169:522–531). To understand the precise role of ETS-1 in angiogenesis, we established both high and low ETS-1 expression EC lines and compared angiogenic properties of these cell lines with those of the parental murine EC line, MSS-31. Although growth rate was almost identical for each cell line, the invasiveness was markedly enhanced in high ETS-1 expression cells and reduced in low ETS-1 expression cells compared with that of parental cells. The gene expressions of matrix metalloproteinases (MMP-1, MMP-3, and MMP-9) and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells. Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin β3. These results indicate that ETS-1 is a principal regulator that converts ECs to the angiogenic phenotype. J Cell Physiol 178:121–132, 1999. © 1999 Wiley-Liss, Inc." @default.
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- W4256292276 date "1999-02-01" @default.
- W4256292276 modified "2023-09-25" @default.
- W4256292276 title "ETS‐1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin β3" @default.
- W4256292276 doi "https://doi.org/10.1002/(sici)1097-4652(199902)178:2<121::aid-jcp1>3.3.co;2-6" @default.
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