Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256298323> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4256298323 endingPage "tw246" @default.
- W4256298323 startingPage "tw246" @default.
- W4256298323 abstract "Sharma and Vijayaraghavan investigated the modulation of neurotransmitter release from quiescent hippocampal neurons and discovered that calcium entering through presynaptic nicotinic acetylcholine receptors (nAChRs) led to bursts of glutamate release that were sufficient to drive the postsynaptic cell to threshold. Resting neurons spontaneously release the contents of individual synaptic vesicles at random intervals. The ensuing miniature postsynaptic potentials, which correspond to individual quanta of the postsynaptic response, are too small to affect firing in the postsynaptic cell, and their physiological function has remained obscure (see Preview by Zucker). Sharma and Vijayaraghavan recorded miniature excitatory postsynaptic currents (mEPSCs) from voltage-clamped CA3 pyramidal cells in rat hippocampal slices before, during, and after local application of nicotine. Nicotine increased the fraction of large mEPSCs in a manner consistent with the concerted release of multiple quanta and stimulated the production of high-frequency bursts of mEPSCs. Pharmacological analysis in combination with manipulation of the extracellular calcium concentration indicated that this increase in mEPSC amplitude and frequency depended on release of calcium from intracellular stores secondary to calcium influx through presynaptic nAChRs. When voltage clamp was released, glutamate released in response to nicotine application initiated bursts of action potentials in the postsynaptic cells. Thus, calcium influx through presynaptic nAChRs appears to provide a mechanism whereby impulses can be generated in the postsynaptic cell independent of the firing of the presynaptic neuron.G. Sharma, S. Vijayaraghavan, Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing. Neuron 38, 929-939 (2003). [Online Journal]R. S. Zucker, Can a synaptic signal arise from noise? Neuron 38, 845-846 (2003). [Online Journal]" @default.
- W4256298323 created "2022-05-12" @default.
- W4256298323 date "2003-07-01" @default.
- W4256298323 modified "2023-09-25" @default.
- W4256298323 title "Maximizing Your Minis" @default.
- W4256298323 doi "https://doi.org/10.1126/scisignal.1892003tw246" @default.
- W4256298323 hasPublicationYear "2003" @default.
- W4256298323 type Work @default.
- W4256298323 citedByCount "0" @default.
- W4256298323 crossrefType "journal-article" @default.
- W4256298323 hasConcept C100837961 @default.
- W4256298323 hasConcept C112592302 @default.
- W4256298323 hasConcept C118232355 @default.
- W4256298323 hasConcept C12554922 @default.
- W4256298323 hasConcept C130316041 @default.
- W4256298323 hasConcept C148785051 @default.
- W4256298323 hasConcept C169760540 @default.
- W4256298323 hasConcept C170493617 @default.
- W4256298323 hasConcept C17077164 @default.
- W4256298323 hasConcept C178790620 @default.
- W4256298323 hasConcept C185263204 @default.
- W4256298323 hasConcept C185592680 @default.
- W4256298323 hasConcept C187102610 @default.
- W4256298323 hasConcept C187541742 @default.
- W4256298323 hasConcept C197341189 @default.
- W4256298323 hasConcept C200170125 @default.
- W4256298323 hasConcept C2910581834 @default.
- W4256298323 hasConcept C41625074 @default.
- W4256298323 hasConcept C519063684 @default.
- W4256298323 hasConcept C55493867 @default.
- W4256298323 hasConcept C61174792 @default.
- W4256298323 hasConcept C86803240 @default.
- W4256298323 hasConceptScore W4256298323C100837961 @default.
- W4256298323 hasConceptScore W4256298323C112592302 @default.
- W4256298323 hasConceptScore W4256298323C118232355 @default.
- W4256298323 hasConceptScore W4256298323C12554922 @default.
- W4256298323 hasConceptScore W4256298323C130316041 @default.
- W4256298323 hasConceptScore W4256298323C148785051 @default.
- W4256298323 hasConceptScore W4256298323C169760540 @default.
- W4256298323 hasConceptScore W4256298323C170493617 @default.
- W4256298323 hasConceptScore W4256298323C17077164 @default.
- W4256298323 hasConceptScore W4256298323C178790620 @default.
- W4256298323 hasConceptScore W4256298323C185263204 @default.
- W4256298323 hasConceptScore W4256298323C185592680 @default.
- W4256298323 hasConceptScore W4256298323C187102610 @default.
- W4256298323 hasConceptScore W4256298323C187541742 @default.
- W4256298323 hasConceptScore W4256298323C197341189 @default.
- W4256298323 hasConceptScore W4256298323C200170125 @default.
- W4256298323 hasConceptScore W4256298323C2910581834 @default.
- W4256298323 hasConceptScore W4256298323C41625074 @default.
- W4256298323 hasConceptScore W4256298323C519063684 @default.
- W4256298323 hasConceptScore W4256298323C55493867 @default.
- W4256298323 hasConceptScore W4256298323C61174792 @default.
- W4256298323 hasConceptScore W4256298323C86803240 @default.
- W4256298323 hasIssue "189" @default.
- W4256298323 hasLocation W42562983231 @default.
- W4256298323 hasOpenAccess W4256298323 @default.
- W4256298323 hasPrimaryLocation W42562983231 @default.
- W4256298323 hasRelatedWork W1512616480 @default.
- W4256298323 hasRelatedWork W1967669335 @default.
- W4256298323 hasRelatedWork W1972972710 @default.
- W4256298323 hasRelatedWork W1995706095 @default.
- W4256298323 hasRelatedWork W2042993105 @default.
- W4256298323 hasRelatedWork W2091421470 @default.
- W4256298323 hasRelatedWork W2111256894 @default.
- W4256298323 hasRelatedWork W2162781578 @default.
- W4256298323 hasRelatedWork W2625872185 @default.
- W4256298323 hasRelatedWork W40473409 @default.
- W4256298323 hasVolume "2003" @default.
- W4256298323 isParatext "false" @default.
- W4256298323 isRetracted "false" @default.
- W4256298323 workType "article" @default.