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- W4256308058 abstract "To assess the relationship between short fetal femur length (FL), measured at the second trimester malformation scan and outcome of pregnancy, in a population where more than 90 % of women attend the first trimester risk assessment. Cohort study of all Danish singleton pregnancies with a second trimester malformation scan between 1 January 2008 and 30 June 2011. Information on FL at the 17–22 week malformation scan, weight and gestational age at delivery, and pre- and postnatal chromosome abnormalities was obtained from the Danish National Fetal Medicine database. Gestational age was based on crown–rump length at the 11–14 week scan or, in case of no first trimester scan, head circumference at second trimester scan. Short FL was defined as below the 5th percentile. Among 147,766 fetuses, short FL was identified in 2718 (1.8%). Short FL was present in 11 (16.2%) of the 68 fetuses affected by Down's syndrome (DS), OR 10.3 (95% CI 5.4-19.7). Trisomy 13/18 and unbalanced autosomal structural abnormalities were also characterized by a short FL in 3 (12.0%, OR 13.3 (95% CI 1.5-119.4) and 8 (30.8%, OR 23.8 (95% CI 10.3-54.7)) of the cases, respectively. The relative risk of the fetus being affected by Trisomy 21, Trisomy 18, Trisomy 13 or unbalanced autosomal structural abnormalities was one to 123 (95% CI 79–192), given a short FL. Pregnancies, in which fetuses had a short FL, were more often affected by early preterm delivery before 34 weeks (5.6%; OR 4.3 (95% CI 3.8-4.8)) and small for gestational age (SGA) infants (13.9%; OR 4.2 (95% CI 3.5-4.9)). A short fetal FL at second trimester malformation scan, is associated with a significantly higher risk of chromosome abnormalities (DS, Trisomy 13, Trisomy 18 and unbalanced autosomal structural abnormalities) as well as SGA and early preterm delivery." @default.
- W4256308058 created "2022-05-12" @default.
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- W4256308058 date "2013-10-01" @default.
- W4256308058 modified "2023-09-27" @default.
- W4256308058 title "OC04.01: Outcome of fetuses with short femur length detected at second trimester malformation scan: a national survey" @default.
- W4256308058 doi "https://doi.org/10.1002/uog.12597" @default.
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