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- W4256359872 abstract "The incidence of Alzheimer's disease (AD) doubles in women. Being age the major risk factor for AD, this difference was thought to be due to women's longer lifespan. However, recent studies suggest that sexual hormones could have an impact on disease progression. The aim of this study is to assess whether there are gender differences in the association between baseline levels of CSF biomarkers for AD (Aβ42, ptau) and for glial activity (YKL40 and sTREM2) and longitudinal brain volume changes in cognitively unimpaired adults. Two brain MRI scans of 36 participants (57 to 78-year-old, 12 male, figure 1) were acquired in a 2-year interval. CSF biomarkers concentration were determined at baseline. sTREM2 was log-transformed to become normally distributed. For each subject, we calculated GM and WM volume change-per-year maps (ΔGM and ΔWM, respectively) by means of longitudinal pairwise registration of SPM12. We voxel-wise determined where the associations between ΔGM, ΔWM and baseline levels of CSF biomarkers depended on gender, correcting for age, gender, TIV, ΔTIV (to deal with potential scanner miscalibrations between scans) and the rest of CSF biomarkers. Statistical threshold was set at p<0.001 uncorrected with a minimum extend of 100 voxels per cluster. Figures 2, 3 and 4 displays gender differences in the association between ΔGM or ΔWM and baseline levels of CSF biomarkers. Figure 5 plots ΔGM or ΔWM values against biomarkers in some of the peaks of areas reported in Figure 2. In some AD regions, the sign of the association between ΔGM or ΔWM and baseline CSF levels of p-tau, YKL40 and sTREM2 differed between genders. It is significant the greater atrophy of medial temporal areas related to high values of CSF-ptau in women than in men No gender differences were observed with respect to Aβ42 associated ΔGM or ΔWM. The greater loss of medial temporal GM in women associated to higher values of CSF ptau may be a mechanism underlying the increased incidence of clinical AD in women. The interaction with sex in medial temporal areas suggest a differential neuroinflammatory response to ptau accumulation between men and women." @default.
- W4256359872 created "2022-05-12" @default.
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- W4256359872 date "2019-07-01" @default.
- W4256359872 modified "2023-10-06" @default.
- W4256359872 title "IC-02-05: GENDER DIFFERENCES IN THE ASSOCIATION BETWEEN LONGITUDINAL BRAIN CHANGES AND BASELINE LEVELS OF CSF ALZHEIMER'S DISEASE AND GLIAL BIOMARKERS IN HEALTHY ELDERS" @default.
- W4256359872 doi "https://doi.org/10.1016/j.jalz.2019.06.4149" @default.
- W4256359872 hasPublicationYear "2019" @default.
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