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- W4256366608 abstract "A1 is an anti-apoptotic bcl gene that is expressed in endothelial cells (EC) in response to pro-inflammatory stimuli. We show that in addition to protecting EC from apoptosis, A1 inhibits EC activation and its associated expression of pro-inflammatory proteins by inhibiting the transcription factor nuclear factor (NF)-κB. This new anti-inflammatory function gives a broader dimension to the protective role of A1 in EC. We also show that activation of NF-κB is essential for the expression of A1. Taken together, our data suggest that A1 downregulates not only the pro-apoptotic and pro-inflammatory response, but also its own expression, thus restoring a quiescent phenotype to EC." @default.
- W4256366608 created "2022-05-12" @default.
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- W4256366608 date "1999-06-01" @default.
- W4256366608 modified "2023-09-28" @default.
- W4256366608 title "Overexpression of A1, an NF-κB–Inducible Anti-Apoptotic Bcl Gene, Inhibits Endothelial Cell Activation" @default.
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- W4256366608 doi "https://doi.org/10.1182/blood.v93.11.3803.411a27_3803_3810" @default.
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