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- W4256376023 abstract "Abstract Besser als das Original : Neuartige Analoga von Apicidin, einem cyclischen Tetrapeptidinhibitor der Histon‐Desacetylase (HDAC), enthalten ein 1,4‐ oder 1,5‐disubstituiertes 1,2,3‐Triazol anstelle einer Gerüst‐Amidbindung, um die entsprechende Bindung in trans ‐ oder cis ‐Konfiguration zu fixieren. So ließ sich die Bindungsaffinität unterschiedlicher Peptidkonformationen (siehe Bild) untersuchen. Ein Analogon erwies sich in einigen Fällen als ein dem Apicidin überlegener HDAC‐Inhibitor. magnified image" @default.
- W4256376023 created "2022-05-12" @default.
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- W4256376023 date "2009-06-09" @default.
- W4256376023 modified "2023-10-18" @default.
- W4256376023 title "Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole‐Modified Cyclic Tetrapeptides" @default.
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- W4256376023 doi "https://doi.org/10.1002/ange.200805900" @default.
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