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- W4256414653 abstract "High resolution glycan analysis has become an important part of biopharmaceutical API production and quality control. Liquid chromatography (LC) is now a well-established technique in this field but the resolution of similar isomeric glycan structures is still a challenge. Here we show that the addition of ion mobility spectroscopy (IMS) in a hyphenated LC-IMS-MS setting allows for the high resolution of N-glycan isomers during positive ion analysis. We have identified unique features in the IM chromatograms to help differentiate a range of isomeric N-glycans for both RFMS labelled glycans and glycopeptides.<br>" @default.
- W4256414653 created "2022-05-12" @default.
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- W4256414653 date "2020-04-20" @default.
- W4256414653 modified "2023-09-24" @default.
- W4256414653 title "Ion-Mobility Mass Spectrometry of Glycans and Glycopeptides Using Both Intact and Glycan Sequencing Approaches In Positive Ion Mode Facilitates Glycan Isomer and Glycan Motif Identification" @default.
- W4256414653 doi "https://doi.org/10.26434/chemrxiv.12117243" @default.
- W4256414653 hasPublicationYear "2020" @default.
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