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- W4256465718 abstract "AbstractBackground: Asthma is a chronic condition that results in the inflammation and narrowing of airways, often clinically presenting as wheeze and shortness of breath. Little is known of the Mechanisms of Action (MOA) of herbs used to treat asthma. The aim of this paper is to review existing data regarding known MOA of Traditional Chinese Medicine which will aid in the understanding of possible interactions between Western drugs and Chinese herbs as well as the standardization of management via a proposed guideline to improve patient safety and possible synergism in the long term. Methods: We searched through 5 databases for commonly prescribed herbs and formulas for asthma, and narrowed down the search to identify the underlying MOA of individual herbs that could specifically target asthma symptoms. We included studies that stated the MOA of individual herbs when used for treating symptoms of asthma, excluding them if they are described as part of a formula. Results: A total of 26 herbs commonly prescribed for asthma with known mechanism of action were identified. Herbs used for asthma were found to have similar MOA as that for drugs. Based on existing GINA guidelines, a guideline is proposed which includes a total of 5 steps depending on the severity of asthma and the herbs’ MOA. 16 formulas were subsequently identified for the management of asthma, which consist of 12 “stand-alone” and 4 “add on” formulas. “Stand-alone” formulas, used independently for asthma generally follow the GINA guidelines but do not proceed beyond step 3. These formulas consist mainly of beta-agonist and steroid-like effects. “Add on” formulas added as adjunct to “stand alone” formulas however, mainly act on T helper cells or have steroid like effects. Conclusion: Through the understanding of MOA of herbs and their respective formulas, it will ensue greater patient safety and outcomes." @default.
- W4256465718 created "2022-05-12" @default.
- W4256465718 creator A5034696862 @default.
- W4256465718 creator A5071128801 @default.
- W4256465718 date "2020-12-30" @default.
- W4256465718 modified "2023-10-17" @default.
- W4256465718 title "Systematic review: Guideline based approach for the management of Asthma and subtypes via Chinese Medicine" @default.
- W4256465718 doi "https://doi.org/10.31219/osf.io/wnhs3" @default.
- W4256465718 hasPublicationYear "2020" @default.
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