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- W4256504406 abstract "Most gastrointestinal stromal tumors (GISTs) have activating mutations in the KIT receptor tyrosine kinase, and most patients with GISTs respond well to Gleevec, which inhibits KIT kinase activity. Here we show that approximately 35% (14 of 40) of GISTs lacking KIT mutations have intragenic activation mutations in the related receptor tyrosine kinase, platelet-derived growth factor receptor alpha (PDGFRA). Tumors expressing KIT or PDGFRA oncoproteins were indistinguishable with respect to activation of downstream signaling intermediates and cytogenetic changes associated with tumor progression. Thus, KIT and PDGFRA mutations appear to be alternative and mutually exclusive oncogenic mechanisms in GISTs. PMID: 12522257" @default.
- W4256504406 created "2022-05-12" @default.
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- W4256504406 date "2003-02-25" @default.
- W4256504406 modified "2023-09-27" @default.
- W4256504406 title "Faculty Opinions recommendation of PDGFRA activating mutations in gastrointestinal stromal tumors." @default.
- W4256504406 doi "https://doi.org/10.3410/f.1012153.184614" @default.
- W4256504406 hasPublicationYear "2003" @default.
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