FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256541911> ?p ?o ?g. }

• W4256541911 endingPage "S483" @default.
• W4256541911 startingPage "S483" @default.
• W4256541911 abstract "Purpose/ObjectiveTo investigate the prognostic significance of HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3), HER4 (c-erb-B4), and phosphorylated Akt (P-Akt) in patients treated with radiation therapy for carcinoma of the cervix.Materials/MethodsBetween 1981 and 1996, fifty-five patients with stages I-IVA carcinoma of the cervix were treated with radiation therapy with definitive intent. Patient records were retrospectively reviewed for clinical parameters and disease status. Immunohistochemistry was performed for HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erbB3), HER4 (c-erbB4), and phosphorylated Akt (P-Akt), and the expression of each biomarker was quantitatively scored by an automated immunohistochemical imaging system (ChromaVision imaging technology).Parametric correlations were performed between biomarkers. Univariate and multivariate analysis were performed with disease-free survival (DFS) and overall survival (OS) as the primary endpoints, and each biomarker was evaluated for correlation between various prognostic pretreatment factors. The Kaplan-Meier method was utilized to evaluate for differences in OS and DFS for specific prognostic factors.ResultsStrong correlations were observed between expression of HER1 and HER4 (p = 0.039), HER2 and HER4 (p = 0.003), and HER3 and HER4 (p = 0.004). Correlations were also made between HER2 and P-Akt with stage of disease at diagnosis (p = 0.004 and p = 0.06, respectively). Only expression of HER4 trended toward a statistically significant correlation with expression of P-Akt (p = 0.07). Decreased HER2, HER4, and P-Akt expression were significant for diminished DFS on univariate analysis (p = 0.01, p = 0.008, and p = 0.02, respectively). Increased HER1, and diminished HER2, HER4, and P-Akt expression were significant or showed trends toward significance for diminished OS on univariate analysis (p = 0.07, p = 0.004, p = 0.08, and p = 0.07, respectively). After controlling for pretreatment factors (stage, grade, and histology), multivariate analysis revealed only HER2 associated with diminished overall survival (p = 0.04).ConclusionsSignificant correlations exist in cervical cancer specimens between expression of transmembrane receptors in the EGFR family. Multivariate analysis revealed only HER2 associated with diminished overall survival after controlling for pretreatment clinical factors. These data emphasize that each member of the EGFR family exhibits differential expression in tumor tissue. Further clinical studies will be required to determine the prognostic significance of these biomarker expression.These data emphasize the importance of continued basic and translational research on the EGFR family of receptors in carcinoma of the cervix Purpose/ObjectiveTo investigate the prognostic significance of HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3), HER4 (c-erb-B4), and phosphorylated Akt (P-Akt) in patients treated with radiation therapy for carcinoma of the cervix. To investigate the prognostic significance of HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3), HER4 (c-erb-B4), and phosphorylated Akt (P-Akt) in patients treated with radiation therapy for carcinoma of the cervix. Materials/MethodsBetween 1981 and 1996, fifty-five patients with stages I-IVA carcinoma of the cervix were treated with radiation therapy with definitive intent. Patient records were retrospectively reviewed for clinical parameters and disease status. Immunohistochemistry was performed for HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erbB3), HER4 (c-erbB4), and phosphorylated Akt (P-Akt), and the expression of each biomarker was quantitatively scored by an automated immunohistochemical imaging system (ChromaVision imaging technology).Parametric correlations were performed between biomarkers. Univariate and multivariate analysis were performed with disease-free survival (DFS) and overall survival (OS) as the primary endpoints, and each biomarker was evaluated for correlation between various prognostic pretreatment factors. The Kaplan-Meier method was utilized to evaluate for differences in OS and DFS for specific prognostic factors. Between 1981 and 1996, fifty-five patients with stages I-IVA carcinoma of the cervix were treated with radiation therapy with definitive intent. Patient records were retrospectively reviewed for clinical parameters and disease status. Immunohistochemistry was performed for HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erbB3), HER4 (c-erbB4), and phosphorylated Akt (P-Akt), and the expression of each biomarker was quantitatively scored by an automated immunohistochemical imaging system (ChromaVision imaging technology). Parametric correlations were performed between biomarkers. Univariate and multivariate analysis were performed with disease-free survival (DFS) and overall survival (OS) as the primary endpoints, and each biomarker was evaluated for correlation between various prognostic pretreatment factors. The Kaplan-Meier method was utilized to evaluate for differences in OS and DFS for specific prognostic factors. ResultsStrong correlations were observed between expression of HER1 and HER4 (p = 0.039), HER2 and HER4 (p = 0.003), and HER3 and HER4 (p = 0.004). Correlations were also made between HER2 and P-Akt with stage of disease at diagnosis (p = 0.004 and p = 0.06, respectively). Only expression of HER4 trended toward a statistically significant correlation with expression of P-Akt (p = 0.07). Decreased HER2, HER4, and P-Akt expression were significant for diminished DFS on univariate analysis (p = 0.01, p = 0.008, and p = 0.02, respectively). Increased HER1, and diminished HER2, HER4, and P-Akt expression were significant or showed trends toward significance for diminished OS on univariate analysis (p = 0.07, p = 0.004, p = 0.08, and p = 0.07, respectively). After controlling for pretreatment factors (stage, grade, and histology), multivariate analysis revealed only HER2 associated with diminished overall survival (p = 0.04). Strong correlations were observed between expression of HER1 and HER4 (p = 0.039), HER2 and HER4 (p = 0.003), and HER3 and HER4 (p = 0.004). Correlations were also made between HER2 and P-Akt with stage of disease at diagnosis (p = 0.004 and p = 0.06, respectively). Only expression of HER4 trended toward a statistically significant correlation with expression of P-Akt (p = 0.07). Decreased HER2, HER4, and P-Akt expression were significant for diminished DFS on univariate analysis (p = 0.01, p = 0.008, and p = 0.02, respectively). Increased HER1, and diminished HER2, HER4, and P-Akt expression were significant or showed trends toward significance for diminished OS on univariate analysis (p = 0.07, p = 0.004, p = 0.08, and p = 0.07, respectively). After controlling for pretreatment factors (stage, grade, and histology), multivariate analysis revealed only HER2 associated with diminished overall survival (p = 0.04). ConclusionsSignificant correlations exist in cervical cancer specimens between expression of transmembrane receptors in the EGFR family. Multivariate analysis revealed only HER2 associated with diminished overall survival after controlling for pretreatment clinical factors. These data emphasize that each member of the EGFR family exhibits differential expression in tumor tissue. Further clinical studies will be required to determine the prognostic significance of these biomarker expression.These data emphasize the importance of continued basic and translational research on the EGFR family of receptors in carcinoma of the cervix Significant correlations exist in cervical cancer specimens between expression of transmembrane receptors in the EGFR family. Multivariate analysis revealed only HER2 associated with diminished overall survival after controlling for pretreatment clinical factors. These data emphasize that each member of the EGFR family exhibits differential expression in tumor tissue. Further clinical studies will be required to determine the prognostic significance of these biomarker expression." @default.
• W4256541911 created "2022-05-12" @default.
• W4256541911 creator A5002947205 @default.
• W4256541911 creator A5026515192 @default.
• W4256541911 creator A5035423539 @default.
• W4256541911 creator A5055986604 @default.
• W4256541911 creator A5057224046 @default.
• W4256541911 creator A5061449102 @default.
• W4256541911 creator A5087383787 @default.
• W4256541911 date "2004-09-01" @default.
• W4256541911 modified "2023-10-17" @default.
• W4256541911 title "Correlation between epidermal growth factor receptor family (HER1, HER2, HER3, HER4), phosphorylated akt (P-AKT) and clinical outcomes after radiation therapy in carcinoma of the cervix" @default.
• W4256541911 doi "https://doi.org/10.1016/s0360-3016(04)01712-2" @default.
• W4256541911 hasPublicationYear "2004" @default.
• W4256541911 type Work @default.
• W4256541911 citedByCount "0" @default.
• W4256541911 crossrefType "journal-article" @default.
• W4256541911 hasAuthorship W4256541911A5002947205 @default.
• W4256541911 hasAuthorship W4256541911A5026515192 @default.
• W4256541911 hasAuthorship W4256541911A5035423539 @default.
• W4256541911 hasAuthorship W4256541911A5055986604 @default.
• W4256541911 hasAuthorship W4256541911A5057224046 @default.
• W4256541911 hasAuthorship W4256541911A5061449102 @default.
• W4256541911 hasAuthorship W4256541911A5087383787 @default.
• W4256541911 hasConcept C11960822 @default.
• W4256541911 hasConcept C121608353 @default.
• W4256541911 hasConcept C126322002 @default.
• W4256541911 hasConcept C143998085 @default.
• W4256541911 hasConcept C170493617 @default.
• W4256541911 hasConcept C2777740455 @default.
• W4256541911 hasConcept C2779438470 @default.
• W4256541911 hasConcept C2908728163 @default.
• W4256541911 hasConcept C29456083 @default.
• W4256541911 hasConcept C502942594 @default.
• W4256541911 hasConcept C530470458 @default.
• W4256541911 hasConcept C54355233 @default.
• W4256541911 hasConcept C71924100 @default.
• W4256541911 hasConcept C75217442 @default.
• W4256541911 hasConcept C86803240 @default.
• W4256541911 hasConceptScore W4256541911C11960822 @default.
• W4256541911 hasConceptScore W4256541911C121608353 @default.
• W4256541911 hasConceptScore W4256541911C126322002 @default.
• W4256541911 hasConceptScore W4256541911C143998085 @default.
• W4256541911 hasConceptScore W4256541911C170493617 @default.
• W4256541911 hasConceptScore W4256541911C2777740455 @default.
• W4256541911 hasConceptScore W4256541911C2779438470 @default.
• W4256541911 hasConceptScore W4256541911C2908728163 @default.
• W4256541911 hasConceptScore W4256541911C29456083 @default.
• W4256541911 hasConceptScore W4256541911C502942594 @default.
• W4256541911 hasConceptScore W4256541911C530470458 @default.
• W4256541911 hasConceptScore W4256541911C54355233 @default.
• W4256541911 hasConceptScore W4256541911C71924100 @default.
• W4256541911 hasConceptScore W4256541911C75217442 @default.
• W4256541911 hasConceptScore W4256541911C86803240 @default.
• W4256541911 hasLocation W42565419111 @default.
• W4256541911 hasOpenAccess W4256541911 @default.
• W4256541911 hasPrimaryLocation W42565419111 @default.
• W4256541911 hasRelatedWork W1967670339 @default.
• W4256541911 hasRelatedWork W2032009340 @default.
• W4256541911 hasRelatedWork W2071396933 @default.
• W4256541911 hasRelatedWork W2164425430 @default.
• W4256541911 hasRelatedWork W2167985694 @default.
• W4256541911 hasRelatedWork W2288576450 @default.
• W4256541911 hasRelatedWork W2319446260 @default.
• W4256541911 hasRelatedWork W2399866110 @default.
• W4256541911 hasRelatedWork W2581581719 @default.
• W4256541911 hasRelatedWork W4296120550 @default.
• W4256541911 hasVolume "60" @default.
• W4256541911 isParatext "false" @default.
• W4256541911 isRetracted "false" @default.
• W4256541911 workType "article" @default.