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- W4256632133 abstract "We thank Lim and colleagues for their letter raising some important points with regard to our suggestion to use genomic information for the identification of cancer antigens [1]. We agree that there might be a need, as Lim et al. suggest, for novel antigen-discovery approaches that complement the classical patient-centered approaches to tumor-antigen identification. Clearly, both the technology used to determine the set of antigens to be further evaluated and interpretation of the expression data merit ongoing scrutiny. The limitations of mRNA and protein expression data are well recognized, failing at times (but not always) to correlate with each other or with the quantity of peptide in the groove of tumor MHC. Of the two universal antigens we discussed in our review [1], telomerase would not have been identified as a tumor antigen solely on the basis of tumor mRNA expression, whereas a cytochrome P450 isoform was identified as an obvious candidate based on comparative SAGE (serial analysis of gene expression) data." @default.
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- W4256632133 date "2002-05-01" @default.
- W4256632133 modified "2023-09-26" @default.
- W4256632133 title "Defining tumor antigens: mRNA, protein or cytotoxicity?" @default.
- W4256632133 doi "https://doi.org/10.1016/s1471-4906(02)02197-x" @default.
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