FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4256677295> ?p ?o ?g. }

• W4256677295 endingPage "9595" @default.
• W4256677295 startingPage "9591" @default.
• W4256677295 abstract "Abstract The cathepsin B inhibitor surugamide B ( 2 ), along with structurally related derivatives (A and C–E), has previously been isolated from the marine actinomycete Streptomyces sp. JAMM992. The biosynthetic genes are unexpectedly part of a cluster of four non‐ribosomal peptide synthetase (NRPS) genes, two of which are responsible for the biosynthesis of the additional linear decapeptide surugamide F. However, the thioesterase domain required for the later stage of the biosynthesis of the cyclic peptides surugamides A–E is not present in any module architecture of the surugamide NRPSs. Herein, we report the first total synthesis of surugamide B ( 2 ) through the macrocyclization at the biomimetic position, which not only alleviated the Cα epimerization in the macrolactamization process, but also efficiently provided 2 in 34 % yield for 18 steps. Furthermore, both the chemical and enzymatic studies with the biosynthetic precursor mimics revealed that the stand‐alone enzyme SurE, which belongs to the penicillin‐binding protein family, is responsible for macrocyclization of the tethered octapeptidyl intermediate." @default.
• W4256677295 created "2022-05-12" @default.
• W4256677295 creator A5023832588 @default.
• W4256677295 creator A5044491238 @default.
• W4256677295 creator A5061922279 @default.
• W4256677295 creator A5064126122 @default.
• W4256677295 creator A5064472249 @default.
• W4256677295 creator A5074774949 @default.
• W4256677295 creator A5075704735 @default.
• W4256677295 creator A5090577049 @default.
• W4256677295 date "2018-06-25" @default.
• W4256677295 modified "2023-10-16" @default.
• W4256677295 title "Total Synthesis of the Nonribosomal Peptide Surugamide B and Identification of a New Offloading Cyclase Family" @default.
• W4256677295 cites W1653566113 @default.
• W4256677295 cites W1970448671 @default.
• W4256677295 cites W1988921452 @default.
• W4256677295 cites W2000455642 @default.
• W4256677295 cites W2041535313 @default.
• W4256677295 cites W2041593863 @default.
• W4256677295 cites W2044863618 @default.
• W4256677295 cites W2046896193 @default.
• W4256677295 cites W2049804099 @default.
• W4256677295 cites W2061278426 @default.
• W4256677295 cites W2098442675 @default.
• W4256677295 cites W2107881585 @default.
• W4256677295 cites W2111689333 @default.
• W4256677295 cites W2116909696 @default.
• W4256677295 cites W2118893440 @default.
• W4256677295 cites W2121194008 @default.
• W4256677295 cites W2156077969 @default.
• W4256677295 cites W2172888731 @default.
• W4256677295 cites W2325467169 @default.
• W4256677295 cites W2326842020 @default.
• W4256677295 cites W2414478913 @default.
• W4256677295 cites W2486542922 @default.
• W4256677295 cites W2546443756 @default.
• W4256677295 cites W2558644420 @default.
• W4256677295 cites W2593112896 @default.
• W4256677295 cites W2623609424 @default.
• W4256677295 cites W2805487264 @default.
• W4256677295 cites W2950859263 @default.
• W4256677295 doi "https://doi.org/10.1002/ange.201805541" @default.
• W4256677295 hasPublicationYear "2018" @default.
• W4256677295 type Work @default.
• W4256677295 citedByCount "7" @default.
• W4256677295 countsByYear W42566772952020 @default.
• W4256677295 countsByYear W42566772952021 @default.
• W4256677295 countsByYear W42566772952022 @default.
• W4256677295 crossrefType "journal-article" @default.
• W4256677295 hasAuthorship W4256677295A5023832588 @default.
• W4256677295 hasAuthorship W4256677295A5044491238 @default.
• W4256677295 hasAuthorship W4256677295A5061922279 @default.
• W4256677295 hasAuthorship W4256677295A5064126122 @default.
• W4256677295 hasAuthorship W4256677295A5064472249 @default.
• W4256677295 hasAuthorship W4256677295A5074774949 @default.
• W4256677295 hasAuthorship W4256677295A5075704735 @default.
• W4256677295 hasAuthorship W4256677295A5090577049 @default.
• W4256677295 hasConcept C104317684 @default.
• W4256677295 hasConcept C181199279 @default.
• W4256677295 hasConcept C185592680 @default.
• W4256677295 hasConcept C203130289 @default.
• W4256677295 hasConcept C2777379556 @default.
• W4256677295 hasConcept C2779281246 @default.
• W4256677295 hasConcept C2779920670 @default.
• W4256677295 hasConcept C2780069284 @default.
• W4256677295 hasConcept C2780622759 @default.
• W4256677295 hasConcept C2909999020 @default.
• W4256677295 hasConcept C36857842 @default.
• W4256677295 hasConcept C523546767 @default.
• W4256677295 hasConcept C54355233 @default.
• W4256677295 hasConcept C553450214 @default.
• W4256677295 hasConcept C55493867 @default.
• W4256677295 hasConcept C60984968 @default.
• W4256677295 hasConcept C67705224 @default.
• W4256677295 hasConcept C71240020 @default.
• W4256677295 hasConcept C86803240 @default.
• W4256677295 hasConcept C88478588 @default.
• W4256677295 hasConceptScore W4256677295C104317684 @default.
• W4256677295 hasConceptScore W4256677295C181199279 @default.
• W4256677295 hasConceptScore W4256677295C185592680 @default.
• W4256677295 hasConceptScore W4256677295C203130289 @default.
• W4256677295 hasConceptScore W4256677295C2777379556 @default.
• W4256677295 hasConceptScore W4256677295C2779281246 @default.
• W4256677295 hasConceptScore W4256677295C2779920670 @default.
• W4256677295 hasConceptScore W4256677295C2780069284 @default.
• W4256677295 hasConceptScore W4256677295C2780622759 @default.
• W4256677295 hasConceptScore W4256677295C2909999020 @default.
• W4256677295 hasConceptScore W4256677295C36857842 @default.
• W4256677295 hasConceptScore W4256677295C523546767 @default.
• W4256677295 hasConceptScore W4256677295C54355233 @default.
• W4256677295 hasConceptScore W4256677295C553450214 @default.
• W4256677295 hasConceptScore W4256677295C55493867 @default.
• W4256677295 hasConceptScore W4256677295C60984968 @default.
• W4256677295 hasConceptScore W4256677295C67705224 @default.
• W4256677295 hasConceptScore W4256677295C71240020 @default.
• W4256677295 hasConceptScore W4256677295C86803240 @default.
• W4256677295 hasConceptScore W4256677295C88478588 @default.
• W4256677295 hasFunder F4320309785 @default.

• next