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- W4256696543 abstract "Abstract Despite the activation of T lymphocytes by antigen-presenting cells is responsible for eliciting antigen-specific immune responses, their crosstalking suffers from temporospatial limitations and endogenous influencing factors, which restrict the generation of a strong antitumor immunity. Here, we describe the manipulation of cross-priming of T cells using biomimetic nanoparticles (BNs) enabled by cascade cell membrane coating. BNs are resulted from coating nanoparticulate substrates with cell membranes extracted from dendritic cells (DCs) that are pre-pulsed with cancer cell membrane-coated nanoparticles. With a DC membrane that presents an array of cancer cell membrane antigen epitopes, BNs inherit intrinsic membrane function of DCs. Strikingly, BNs can directly cross-prime T cells and provoke robust yet antigen-specific antitumor responses in multiple mouse models. Combination with clinical anti-programmed death-1 antibodies demonstrates a practical way of BNs to achieve desirable tumor regression and survival rate. This work spotlights the impact of nanoparticles on direct cross-priming of T cells and supports a unique yet modulate platform for boosting an effective adaptive immunity for immunotherapy." @default.
- W4256696543 created "2022-05-12" @default.
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- W4256696543 date "2021-07-15" @default.
- W4256696543 modified "2023-09-28" @default.
- W4256696543 title "Biomimetic nanoparticles enabled by cascade cell membrane coating for direct cross-priming of T cells" @default.
- W4256696543 doi "https://doi.org/10.21203/rs.3.rs-79607/v1" @default.
- W4256696543 hasPublicationYear "2021" @default.
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