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- W4256702973 abstract "Five groups of four, housed Cheviot ewes (mean liveweight 50 kg) were given single doses of 0, 2·5, 5, 10 or 20 g cupric oxide particles in gelatin capsules while receiving a diet of marginal copper content based on pelleted oats. After 65 days liver copper concentrations had increased curvilinearly in relation to dose and all ewes given 10 or 20 g cupric oxide particles showed increases of at least 13·4 mmol kg−1 dry matter (850 ppm). Liver copper concentrations had generally declined after 85 days but biochemical and histological evidence of copper toxicity was recorded in one ewe which had received 20 g cupric oxide particles. Despite marked variations between individual sheep a dose of 0·1 g kg−1 liveweight (5 g) was considered to be safe and did not induce clinical copper toxicity in five sheep of the susceptible North Ronaldsay breed given the same basal diet." @default.
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- W4256702973 date "1987-03-01" @default.
- W4256702973 modified "2023-10-16" @default.
- W4256702973 title "Safety and effectiveness of cupric oxide particles for increasing liver copper stores in sheep" @default.
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- W4256702973 doi "https://doi.org/10.1016/s0034-5288(18)30689-1" @default.
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