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• W4256707104 abstract "ABSTRACT Introduction Antiandrogen therapy has been used for 30 years to treat paraphilic patients and sexual offenders. Yet the therapeutic success of antiandrogens is uncertain. Furthermore, there is still a lack of comprehensive knowledge about the effects of androgen-lowering therapy in paraphilic patients. Aim This article reviews current neurobiological and clinical knowledge about testosterone and its impact on sexuality, acquired from animal and human basic research. This knowledge may not only enhance our understanding of the great variability of the therapeutic outcome, but could also offer new opportunities to evaluate the effect of androgen-lowering therapy in paraphilia. Methods A comprehensive review of the human and animal literature is presented, considering the classical and non-classical mechanisms of androgens and the androgen brain receptors. Furthermore, the clinical evidence about the impact of testosterone on human sexual behavior is discussed. These are integrated into two current neurobiological theories of sexual behavior, the four-component model and the dual-control model. Results The wide distribution of androgen receptors throughout the whole brain and their numerous mechanisms demonstrate that androgens can modulate almost every aspect of sexual behavior—i.e., not only autonomic functions, but also emotional, motivational, and cognitive aspects. Furthermore, testosterone participates in excitatory and inhibitory processes of sexual functions by modulating the activity of mainly dopaminergic neurotransmitter systems. Conclusions Using the data presented, we combine the two models and present a new integrated approach to understand the role of testosterone in the excitation and inhibition of sexual function, at the neurochemical, neuroanatomical, and behavioral levels. This knowledge will help us to gain a better understanding of the few and inconsistent data that are currently available concerning (i) the association between testosterone and paraphilic behavior; and (ii) the highly variable effects of antiandrogen therapy, discussed in Part II of this review." @default.
• W4256707104 created "2022-05-12" @default.
• W4256707104 creator A5036724704 @default.
• W4256707104 creator A5059926804 @default.
• W4256707104 creator A5070754516 @default.
• W4256707104 creator A5085112411 @default.
• W4256707104 date "2011-11-01" @default.
• W4256707104 modified "2023-10-16" @default.
• W4256707104 title "The Role of Testosterone in Sexuality and Paraphilia—A Neurobiological Approach. Part I: Testosterone and Sexuality" @default.
• W4256707104 cites W1485231747 @default.
• W4256707104 cites W1561532865 @default.
• W4256707104 cites W1586117512 @default.
• W4256707104 cites W1964739820 @default.
• W4256707104 cites W1965283193 @default.
• W4256707104 cites W1972736300 @default.
• W4256707104 cites W1974255487 @default.
• W4256707104 cites W1975768376 @default.
• W4256707104 cites W1977601944 @default.
• W4256707104 cites W1978648280 @default.
• W4256707104 cites W1980117298 @default.
• W4256707104 cites W1981834521 @default.
• W4256707104 cites W1984397639 @default.
• W4256707104 cites W1985453907 @default.
• W4256707104 cites W1990168204 @default.
• W4256707104 cites W1992357100 @default.
• W4256707104 cites W1993270382 @default.
• W4256707104 cites W1995878014 @default.
• W4256707104 cites W1998518744 @default.
• W4256707104 cites W2000715869 @default.
• W4256707104 cites W2003179770 @default.
• W4256707104 cites W2005656524 @default.
• W4256707104 cites W2010553498 @default.
• W4256707104 cites W2013945619 @default.
• W4256707104 cites W2014179562 @default.
• W4256707104 cites W2019944403 @default.
• W4256707104 cites W2022214811 @default.
• W4256707104 cites W2023500766 @default.
• W4256707104 cites W2023572385 @default.
• W4256707104 cites W2024496930 @default.
• W4256707104 cites W2026810208 @default.
• W4256707104 cites W2028820829 @default.
• W4256707104 cites W2029241696 @default.
• W4256707104 cites W2031475842 @default.
• W4256707104 cites W2032888140 @default.
• W4256707104 cites W2034161133 @default.
• W4256707104 cites W2037104330 @default.
• W4256707104 cites W2038601419 @default.
• W4256707104 cites W2040008722 @default.
• W4256707104 cites W2042179361 @default.
• W4256707104 cites W2042901085 @default.
• W4256707104 cites W2044970885 @default.
• W4256707104 cites W2047844288 @default.
• W4256707104 cites W2048856370 @default.
• W4256707104 cites W2048904404 @default.
• W4256707104 cites W2050581082 @default.
• W4256707104 cites W2050602600 @default.
• W4256707104 cites W2051220055 @default.
• W4256707104 cites W2051552569 @default.
• W4256707104 cites W2051653212 @default.
• W4256707104 cites W2052241113 @default.
• W4256707104 cites W2053608868 @default.
• W4256707104 cites W2057426299 @default.
• W4256707104 cites W2057645368 @default.
• W4256707104 cites W2060324329 @default.
• W4256707104 cites W2064710061 @default.
• W4256707104 cites W2067580080 @default.
• W4256707104 cites W2072447154 @default.
• W4256707104 cites W2075959050 @default.
• W4256707104 cites W2081159649 @default.
• W4256707104 cites W2081358654 @default.
• W4256707104 cites W2084631850 @default.
• W4256707104 cites W2088113331 @default.
• W4256707104 cites W2089582977 @default.
• W4256707104 cites W2096533125 @default.
• W4256707104 cites W2097773217 @default.
• W4256707104 cites W2102998829 @default.
• W4256707104 cites W2104178671 @default.
• W4256707104 cites W2116323082 @default.
• W4256707104 cites W2116409093 @default.
• W4256707104 cites W2117604814 @default.
• W4256707104 cites W2118422387 @default.
• W4256707104 cites W2119261700 @default.
• W4256707104 cites W2120959024 @default.
• W4256707104 cites W2121855288 @default.
• W4256707104 cites W2124095790 @default.
• W4256707104 cites W2130978506 @default.
• W4256707104 cites W2135392397 @default.
• W4256707104 cites W2135558083 @default.
• W4256707104 cites W2135775916 @default.
• W4256707104 cites W2138141643 @default.
• W4256707104 cites W2139840896 @default.
• W4256707104 cites W2142453338 @default.
• W4256707104 cites W2146833117 @default.
• W4256707104 cites W2149678354 @default.
• W4256707104 cites W2150113303 @default.
• W4256707104 cites W2150397128 @default.
• W4256707104 cites W2156872462 @default.
• W4256707104 cites W2158447906 @default.

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