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• W425743025 abstract "AIM:To investigate the expression of survivin and its relationship with proliferation and apoptosis in colorectal adenoma and adenocarcinoma. METHODS:Using terminal deoxynucleotidyl transferasemediated dUTP nick end labeling (TUNEL) and immuno histochemistry S-P method, the authors examined the expression of survivin, Ki-67 and apoptotic cell in situ in 60 cases of colorectal adenocarcinoma, 35 adenoma and 20 normal colonic mucosa. RESULTS:Survivin expression was observed in 36 of 60 (60.0 %) cases of colorectal adenocarcinoma and in 6 of 35 (17.1 %) cases of adenoma. In contrast, normal colonic mucosa did not express survivin. Overexpression of survivin was related to the differentiation grade of colorectal adenocarcinoma, however there was no correlation with Dukes’s stage of lymph node metastasis. Ki-67 labeling index (LI) was higher in colorectal adenocarcinoma than that in adenoma (39.1± 10.4 % versus 22.3± 6.2 %, P <0.01). The apoptosis index (AI) of colorectal adenocarcinoma and adenoma was significantly higher than that of normal tissues (P <0.01). More apoptotic cells were noticed in well and moderate differentiated adenocarcinoma than those in poorly differentiated adenocarcinoma (P <0.05). Survivin positive adenoma and adenocarcinoma had significantly lower values for AI than survivin negative tumors (P <0.01), and the Ki-67 LI in survivin positive adenoma and adenocarcinoma were higher than that in survivin negative tumors (P <0.01)." @default.
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• W425743025 date "2003-05-15" @default.
• W425743025 modified "2023-09-27" @default.
• W425743025 title "Expression of survivin protein in colorectal adenocarcinoma" @default.
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• W425743025 doi "https://doi.org/10.11569/wcjd.v11.i5.540" @default.
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