Matches in SemOpenAlex for { <https://semopenalex.org/work/W426383> ?p ?o ?g. }
- W426383 endingPage "292" @default.
- W426383 startingPage "273" @default.
- W426383 abstract "Arachidonic acid (AA) is metabolized by the cyclo-oxygenase and the lipoxygenase pathways to give a number of products, some of which have potent and sometimes opposing biological activities. Different cell types produce different metabolites, so that the chief AA metabolite produced by the platelet is the pro-aggregatory thromboxane A2 (TXA2), whereas that produced by the vascular endothelium is the anti-aggregatory prostacyclin. White blood cells, on the other hand, are the chief source of the leukotrienes, which are implicated in the inflammatory process. Generation of these products may be modified in certain pathological conditions, such as atherosclerosis and diabetes, where prostacyclin synthesis is reduced and TXA2 synthesis increased, resulting in a pro-thrombotic state. Synthesis of AA metabolites may be inhibited, either totally or selectively, using drugs which inhibit different enzymes in the metabolic pathway. These drugs may be beneficial in the treatment of thrombotic disorders and inflammation. AA metabolism may also be modified by dietary substitution with eicosapentaenoic acid, a fatty acid present in fish oils." @default.
- W426383 created "2016-06-24" @default.
- W426383 creator A5003430014 @default.
- W426383 creator A5005357835 @default.
- W426383 date "1986-05-01" @default.
- W426383 modified "2023-10-06" @default.
- W426383 title "1 Arachidonate Metabolism in Blood Cells and the Vessel Wall" @default.
- W426383 cites W1493497290 @default.
- W426383 cites W156046135 @default.
- W426383 cites W1563691568 @default.
- W426383 cites W1597746336 @default.
- W426383 cites W1965614591 @default.
- W426383 cites W1967510388 @default.
- W426383 cites W1968232791 @default.
- W426383 cites W1970518771 @default.
- W426383 cites W1970777502 @default.
- W426383 cites W1973832079 @default.
- W426383 cites W1977384797 @default.
- W426383 cites W1978568416 @default.
- W426383 cites W1978883377 @default.
- W426383 cites W1980197284 @default.
- W426383 cites W1980817754 @default.
- W426383 cites W1981054907 @default.
- W426383 cites W1981159906 @default.
- W426383 cites W1984278454 @default.
- W426383 cites W1985186831 @default.
- W426383 cites W1986268706 @default.
- W426383 cites W1986603676 @default.
- W426383 cites W1986802467 @default.
- W426383 cites W1987146416 @default.
- W426383 cites W1988783155 @default.
- W426383 cites W1989246667 @default.
- W426383 cites W1989523447 @default.
- W426383 cites W1989856248 @default.
- W426383 cites W1992220924 @default.
- W426383 cites W1996578461 @default.
- W426383 cites W1999590350 @default.
- W426383 cites W2000129813 @default.
- W426383 cites W2002122576 @default.
- W426383 cites W2005958975 @default.
- W426383 cites W2006756157 @default.
- W426383 cites W2007625223 @default.
- W426383 cites W2010694924 @default.
- W426383 cites W2010751083 @default.
- W426383 cites W2013326675 @default.
- W426383 cites W2013682830 @default.
- W426383 cites W2014414645 @default.
- W426383 cites W2014488440 @default.
- W426383 cites W2019900301 @default.
- W426383 cites W2025237854 @default.
- W426383 cites W2026913755 @default.
- W426383 cites W2027700946 @default.
- W426383 cites W2027869711 @default.
- W426383 cites W2028572729 @default.
- W426383 cites W2030087792 @default.
- W426383 cites W2030714947 @default.
- W426383 cites W2030768867 @default.
- W426383 cites W2033277030 @default.
- W426383 cites W2033689648 @default.
- W426383 cites W2033773147 @default.
- W426383 cites W2037267173 @default.
- W426383 cites W2037850697 @default.
- W426383 cites W2038443634 @default.
- W426383 cites W2038791603 @default.
- W426383 cites W2041201175 @default.
- W426383 cites W2041471457 @default.
- W426383 cites W2041735424 @default.
- W426383 cites W2045461798 @default.
- W426383 cites W2047206656 @default.
- W426383 cites W2048050761 @default.
- W426383 cites W2049399588 @default.
- W426383 cites W2050568232 @default.
- W426383 cites W2054159467 @default.
- W426383 cites W2054262691 @default.
- W426383 cites W2054631446 @default.
- W426383 cites W2055000155 @default.
- W426383 cites W2058440862 @default.
- W426383 cites W2061580340 @default.
- W426383 cites W2061756688 @default.
- W426383 cites W2062604592 @default.
- W426383 cites W2065134394 @default.
- W426383 cites W2065234246 @default.
- W426383 cites W2065583843 @default.
- W426383 cites W2065732704 @default.
- W426383 cites W2071725016 @default.
- W426383 cites W2072084959 @default.
- W426383 cites W2072886261 @default.
- W426383 cites W2074249021 @default.
- W426383 cites W2075541661 @default.
- W426383 cites W2076531282 @default.
- W426383 cites W2077707942 @default.
- W426383 cites W2077991340 @default.
- W426383 cites W2080708901 @default.
- W426383 cites W2080750144 @default.
- W426383 cites W2083801539 @default.
- W426383 cites W2086838778 @default.
- W426383 cites W2087186913 @default.
- W426383 cites W2087895681 @default.