Matches in SemOpenAlex for { <https://semopenalex.org/work/W42654110> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W42654110 endingPage "5" @default.
- W42654110 startingPage "121" @default.
- W42654110 abstract "The objective of this study was to compare the pharmacokinetics of serum estradiol concentrations after application of two different transdermal estradiol delivery systems. Ten postmenopausal women (E2 < or = 30 pg/ml; follicle-stimulating hormone > or = 30 mIE/ml) were prospectively randomized to a crossover treatment protocol separated by a 7-day wash out period. The absorption of estradiol was measured after application of a patch either containing 4.0 mg of E2 in a reservoir system or 1.8 mg of E2 in a specially designed matrix system. Although the increase of serum estradiol concentrations after application of the patches with the matrix system was slightly delayed, mean E2 levels over the whole observation period of 80 hours were significantly higher than those achieved with the reservoir system (difference of mean values: 5.1 pg/ml; p < 0.05). This observation was most striking at the end of the observation period and after removal of the patches. Yet, fluctuations of hormone concentrations were greater with the matrix system patches, and the areas under the E2 concentration-time curves were slightly but not significantly increased as compared to these of the patches with the reservoir system (3211 +/- 584 vs. 2556 +/- 249 pg/ml x h). In conclusion, both transdermal estradiol delivery systems are well suited for postmenopausal hormone substitution providing stable serum estradiol concentrations at about 50 pg/ml, with the matrix system possibly increasing the life span of the patch and thus the recommended application period." @default.
- W42654110 created "2016-06-24" @default.
- W42654110 creator A5009205531 @default.
- W42654110 creator A5011873271 @default.
- W42654110 creator A5028958850 @default.
- W42654110 creator A5060111105 @default.
- W42654110 date "1998-01-01" @default.
- W42654110 modified "2023-09-23" @default.
- W42654110 title "[Bioavailability of 17 beta-estradiol after transdermal administration--dependence on the patch system]." @default.
- W42654110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9556902" @default.
- W42654110 hasPublicationYear "1998" @default.
- W42654110 type Work @default.
- W42654110 sameAs 42654110 @default.
- W42654110 citedByCount "0" @default.
- W42654110 crossrefType "journal-article" @default.
- W42654110 hasAuthorship W42654110A5009205531 @default.
- W42654110 hasAuthorship W42654110A5011873271 @default.
- W42654110 hasAuthorship W42654110A5028958850 @default.
- W42654110 hasAuthorship W42654110A5060111105 @default.
- W42654110 hasConcept C112705442 @default.
- W42654110 hasConcept C126322002 @default.
- W42654110 hasConcept C134018914 @default.
- W42654110 hasConcept C142724271 @default.
- W42654110 hasConcept C181389837 @default.
- W42654110 hasConcept C204787440 @default.
- W42654110 hasConcept C205679159 @default.
- W42654110 hasConcept C27081682 @default.
- W42654110 hasConcept C2775842315 @default.
- W42654110 hasConcept C2777164284 @default.
- W42654110 hasConcept C2779076696 @default.
- W42654110 hasConcept C2779755712 @default.
- W42654110 hasConcept C2908647359 @default.
- W42654110 hasConcept C2986817661 @default.
- W42654110 hasConcept C71315377 @default.
- W42654110 hasConcept C71924100 @default.
- W42654110 hasConcept C87813604 @default.
- W42654110 hasConcept C98274493 @default.
- W42654110 hasConcept C99454951 @default.
- W42654110 hasConceptScore W42654110C112705442 @default.
- W42654110 hasConceptScore W42654110C126322002 @default.
- W42654110 hasConceptScore W42654110C134018914 @default.
- W42654110 hasConceptScore W42654110C142724271 @default.
- W42654110 hasConceptScore W42654110C181389837 @default.
- W42654110 hasConceptScore W42654110C204787440 @default.
- W42654110 hasConceptScore W42654110C205679159 @default.
- W42654110 hasConceptScore W42654110C27081682 @default.
- W42654110 hasConceptScore W42654110C2775842315 @default.
- W42654110 hasConceptScore W42654110C2777164284 @default.
- W42654110 hasConceptScore W42654110C2779076696 @default.
- W42654110 hasConceptScore W42654110C2779755712 @default.
- W42654110 hasConceptScore W42654110C2908647359 @default.
- W42654110 hasConceptScore W42654110C2986817661 @default.
- W42654110 hasConceptScore W42654110C71315377 @default.
- W42654110 hasConceptScore W42654110C71924100 @default.
- W42654110 hasConceptScore W42654110C87813604 @default.
- W42654110 hasConceptScore W42654110C98274493 @default.
- W42654110 hasConceptScore W42654110C99454951 @default.
- W42654110 hasIssue "3" @default.
- W42654110 hasLocation W426541101 @default.
- W42654110 hasOpenAccess W42654110 @default.
- W42654110 hasPrimaryLocation W426541101 @default.
- W42654110 hasRelatedWork W2018782703 @default.
- W42654110 hasRelatedWork W2022136417 @default.
- W42654110 hasRelatedWork W2045833130 @default.
- W42654110 hasRelatedWork W2065783198 @default.
- W42654110 hasRelatedWork W2092031009 @default.
- W42654110 hasRelatedWork W2113024085 @default.
- W42654110 hasRelatedWork W2158216542 @default.
- W42654110 hasRelatedWork W2390489367 @default.
- W42654110 hasRelatedWork W2425346622 @default.
- W42654110 hasRelatedWork W2469996695 @default.
- W42654110 hasVolume "120" @default.
- W42654110 isParatext "false" @default.
- W42654110 isRetracted "false" @default.
- W42654110 magId "42654110" @default.
- W42654110 workType "article" @default.