Matches in SemOpenAlex for { <https://semopenalex.org/work/W426596285> ?p ?o ?g. }
- W426596285 endingPage "2337" @default.
- W426596285 startingPage "2326" @default.
- W426596285 abstract "Protozoan parasites of the family Trypanosomatidae infect humans as well as livestock causing devastating diseases like sleeping sickness, Chagas disease, and Leishmaniasis. These parasites compartmentalize glycolytic enzymes within unique organelles, the glycosomes. Glycosomes represent a subclass of peroxisomes and they are essential for the parasite survival. Hence, disruption of glycosome biogenesis is an attractive drug target for these Neglected Tropical Diseases (NTDs). Peroxin 16 (PEX16) plays an essential role in peroxisomal membrane protein targeting and de novo biogenesis of peroxisomes from endoplasmic reticulum (ER). We identified trypanosomal PEX16 based on specific sequence characteristics and demonstrate that it is an integral glycosomal membrane protein of procyclic and bloodstream form trypanosomes. RNAi mediated partial knockdown of Trypanosoma brucei PEX16 in bloodstream form trypanosomes led to severe ATP depletion, motility defects and cell death. Microscopic and biochemical analysis revealed drastic reduction in glycosome number and mislocalization of the glycosomal matrix enzymes to the cytosol. Asymmetry of the localization of the remaining glycosomes was observed with a severe depletion in the posterior part. The results demonstrate that trypanosomal PEX16 is essential for glycosome biogenesis and thereby, provides a potential drug target for sleeping sickness and related diseases." @default.
- W426596285 created "2016-06-24" @default.
- W426596285 creator A5012995576 @default.
- W426596285 creator A5017591731 @default.
- W426596285 creator A5037710435 @default.
- W426596285 date "2015-10-01" @default.
- W426596285 modified "2023-10-01" @default.
- W426596285 title "Identification and functional characterization of Trypanosoma brucei peroxin 16" @default.
- W426596285 cites W184565012 @default.
- W426596285 cites W1964869212 @default.
- W426596285 cites W1971807222 @default.
- W426596285 cites W1973449480 @default.
- W426596285 cites W1973663127 @default.
- W426596285 cites W1979720390 @default.
- W426596285 cites W1981022751 @default.
- W426596285 cites W1981109259 @default.
- W426596285 cites W1986212888 @default.
- W426596285 cites W1996689433 @default.
- W426596285 cites W2003399160 @default.
- W426596285 cites W2004899695 @default.
- W426596285 cites W2014238612 @default.
- W426596285 cites W2014664955 @default.
- W426596285 cites W2015620110 @default.
- W426596285 cites W2015637535 @default.
- W426596285 cites W2019085219 @default.
- W426596285 cites W2022348939 @default.
- W426596285 cites W2022799087 @default.
- W426596285 cites W2025446497 @default.
- W426596285 cites W2026841115 @default.
- W426596285 cites W2028538636 @default.
- W426596285 cites W2032947287 @default.
- W426596285 cites W2033044759 @default.
- W426596285 cites W2038384001 @default.
- W426596285 cites W2039903260 @default.
- W426596285 cites W2041941555 @default.
- W426596285 cites W2043414371 @default.
- W426596285 cites W2043839995 @default.
- W426596285 cites W2045914902 @default.
- W426596285 cites W2048244925 @default.
- W426596285 cites W2054727756 @default.
- W426596285 cites W2055539014 @default.
- W426596285 cites W2069628331 @default.
- W426596285 cites W2070177077 @default.
- W426596285 cites W2074955861 @default.
- W426596285 cites W2081707121 @default.
- W426596285 cites W2087554753 @default.
- W426596285 cites W2093822146 @default.
- W426596285 cites W2095001956 @default.
- W426596285 cites W2100512544 @default.
- W426596285 cites W2101036956 @default.
- W426596285 cites W2103186456 @default.
- W426596285 cites W2104482284 @default.
- W426596285 cites W2107195583 @default.
- W426596285 cites W2115815568 @default.
- W426596285 cites W2125918528 @default.
- W426596285 cites W2127019764 @default.
- W426596285 cites W2127694674 @default.
- W426596285 cites W2127705862 @default.
- W426596285 cites W2131749603 @default.
- W426596285 cites W2132242617 @default.
- W426596285 cites W2132681961 @default.
- W426596285 cites W2133963159 @default.
- W426596285 cites W2136970996 @default.
- W426596285 cites W2137801510 @default.
- W426596285 cites W2138712265 @default.
- W426596285 cites W2144973878 @default.
- W426596285 cites W2147357144 @default.
- W426596285 cites W2155817635 @default.
- W426596285 cites W2157236463 @default.
- W426596285 cites W2158427156 @default.
- W426596285 cites W2161988080 @default.
- W426596285 cites W2171631681 @default.
- W426596285 doi "https://doi.org/10.1016/j.bbamcr.2015.05.024" @default.
- W426596285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26025675" @default.
- W426596285 hasPublicationYear "2015" @default.
- W426596285 type Work @default.
- W426596285 sameAs 426596285 @default.
- W426596285 citedByCount "24" @default.
- W426596285 countsByYear W4265962852016 @default.
- W426596285 countsByYear W4265962852017 @default.
- W426596285 countsByYear W4265962852018 @default.
- W426596285 countsByYear W4265962852019 @default.
- W426596285 countsByYear W4265962852020 @default.
- W426596285 countsByYear W4265962852021 @default.
- W426596285 countsByYear W4265962852022 @default.
- W426596285 countsByYear W4265962852023 @default.
- W426596285 crossrefType "journal-article" @default.
- W426596285 hasAuthorship W426596285A5012995576 @default.
- W426596285 hasAuthorship W426596285A5017591731 @default.
- W426596285 hasAuthorship W426596285A5037710435 @default.
- W426596285 hasBestOaLocation W4265962851 @default.
- W426596285 hasConcept C104317684 @default.
- W426596285 hasConcept C12296475 @default.
- W426596285 hasConcept C127078168 @default.
- W426596285 hasConcept C131934819 @default.
- W426596285 hasConcept C142724271 @default.
- W426596285 hasConcept C155432671 @default.
- W426596285 hasConcept C158617107 @default.